ISHIMARU YOSHIRO    Department   Undergraduate School  , School of Agriculture    Position   Professor
Research Period	2016/04～2019/03
Research Topic	Physiological function of the receptor expressing intestinal tuft cells and screening of its inhibitors
Research Type	KAKENHI Research
Consignor	Japan Society for the Promotion of Science
Research Program Type	Grant-in-Aid for Scientific Research (B)
KAKENHI Grant No.	16H04919
Responsibility	Representative Researcher
Representative Person	ISHIMARU Yoshiro
Details	To elucidate the function of the orphan receptor Gprc5c, which is expressed in intestinal tuft cells, in vivo, we generated its knockout mice by new genome editing methods, TALEN and CRISPER/Cas9 and analyzed its phenotypes. KO mice have reduced body weight. Infection experiments showed that Gprc5c may not be involved in type 2 innate immune response against nematode, Nippostrongylus brasiliensis, infection.