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SHIMADA TOMOHIRO
Department Undergraduate School , School of Agriculture Position Associate Professor |
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| Language | English |
| Publication Date | 2014/05 |
| Type | Academic Journal |
| Peer Review | Peer reviewed |
| Title | Roles of cell division control factor SdiA: recognition of quorum sensing signals and modulation of transcription regulation targets. |
| Contribution Type | Co-authored (first author) |
| Journal | Genes to cells : devoted to molecular & cellular mechanisms |
| Journal Type | Another Country |
| Volume, Issue, Page | 19(5),pp.405-18 |
| Authorship | Lead author |
| Author and coauthor | Shimada Tomohiro, Shimada Kaori, Matsui Makoto, Kitai Yuichi, Igarashi Jun, Suga Hiroaki, Ishihama Akira |
| Details | In Gram-negative bacteria, N-acylhomoserine lactone (HSL) is used as a signal in cell-cell communication and quorum sensing (QS). The model prokaryote Escherichia coli lacks the system of HSL synthesis, but is capable of monitoring HSL signals in environment. Transcription factor SdiA for cell division control is believed to play a role as a HSL sensor. Using a collection of 477 species of chemically synthesized HSL analogues, we identified three synthetic signal molecules (SSMs) that bind in vitro to purified SdiA. After SELEX-chip screening of SdiA-binding DNA sequences, a striking difference was found between these SSMs in the pattern of regulation target genes on the E. coli genome. ... |
| DOI | 10.1111/gtc.12139 |
| ISSN | 1365-2443 |
| PMID | 24645791 |