Faculty Database - Hiraoka Wakako

（Last updated : 2020-03-24 13:52:28）

Hiraoka Wakako
Department Undergraduate School , School of Science and Technology

Position Professor

■ Books and Papers

1.	2019/11	Article	Inositol hexaphosphate-induced cellular response in myeloid leukemia cells is mediated by nicotinamide adenine dinucleotide phosphate oxidase activation Fujita Medical Journal 5(4),pp.98-103 (Collaboration)
2.	2019/09	Article	Nucleoside analogs as a radiosensitizer modulating DNA repair, cell cycle checkpoints, and apoptosis. Nucleosides, nucleotides & nucleic acids pp.1-14 (Collaboration)
3.	2018/08	Article	Genotoxic Responses of Mitochondrial Oxygen Consumption Rate and Mitochondrial Semiquinone Radicals in Tumor Cells Applied Magnetic Resonance 49(8),pp.837-851 (Collaboration)
4.	2018/06	Article	Evaluation of mitochondrial redox status and energy metabolism of X-irradiated HeLa cells by LC/UV, LC/MS/MS and ESR. Free Radical Research 52(6),pp.648-660 (Collaboration)
5.	2012/11	Article	Effect of the Interaction between IP6 and ROS on Cell Proliferation and Cell Differentiation. FREE RADICAL BIOLOGY & MEDICINE 53(Supplement 2),pp.S148 (Collaboration)
6.	2012/09	Article	Crucial role of reactive oxygen intermediates in 1,25-dihydroxyvitamin D3 and phorbol 12-myristate 13-acetate (PMA)-induced monocytic differentiation of myeloid leukemia PLB-985 cells. FREE RADICAL BIOLOGY & MEDICINE 53(Supplement 1),pp.S164 (Collaboration)
7.	2008/02	Article	Instability of familial spongiform encephalopathy-related prion mutants. Biochem. Biophys. Res. Commun. 366(1),pp.244-249 (Collaboration)
8.	2008/02	Article	Sonodynamic effect of photosensitizers : The enhancement of cell killing by a radical independent mechanism. Photomedicine and Photobiology 29,pp.4-7 (Collaboration)
9.	2007	Article	Effect of OH radicals induced by 1 MHz-ultrasound on HeLa Cells. IEICE Technical Report US2007(73),pp.39-43 (Collaboration)
10.	2003/09	Article	Ca(2+)-dependent and caspase-3-independent apoptosis caused by damage in Golgi apparatus due to 2,4,5,7-tetrabromorhodamine 123 bromide-induced photodynamic effects. Photochemistry and Photobiology 78(3),pp.241-247 (Collaboration)
11.	2001/03	Article	Analysis of reactive oxygen intermediates generated in PC-12 cells by ESR-spin trapping method Magnetic Resonance in Medicine 12巻,pp.72-75 (Collaboration)
12.	2001/03	Article	Analysis of reactive oxygen intermediutes in PLB-985 cells after 9-cis-retinoic acid induced differentiation with ESR-spin trapping Magnetic Resonance in Medicine 12巻,pp.76-79 (Collaboration)
13.	1999/10	Article	Effects of BAPTA-AM and forskolin on apoptosis and cytochrome c release in photosensitized Chinese hamster V79 cells. the American Society for PhotobiologyPhotochem.Photobiol. 70･4,pp.650-655 (Collaboration)
14.	1998/12	Article	Radiation-and reactive oxygen-induced cell death and signal trans duction in cultured mammalian cells AOCS Press pp.14-21 (Collaboration)
15.	1998/12	Article	Role of oxygen radicals generated by NADPH oxidase in apoptosis induced in human leukemia cells The Journals of Clinical Investigations 102巻11号,pp.1961-1968 (Collaboration)
16.	1998/06	Article	Concentration-dependent Mode of cell death in Chinese hamster V79 Cells after treatment with H2O2 Journal of Radiation Research 38巻,pp.95-102 (Collaboration)
17.	1991	Article	Characterization of free radicals in gamma-irradiated polycrystalline uridine 5'-monophosphate:a study combining ESR and spin-trapping Taylar and FransisInternational Journal of Radiation Biology 55,pp.51-58 (Collaboration)
18.	1991	Article	Reactions and rate constants between hydrated electrons and the monomer an dimer of 2-methyl 2-nitrosopropane determined by the pulse radiolysis method. American Chemical SocietyJournal of American Chemical Society 113,pp.3995-3997 (Collaboration)
19.	1990	Article	Free-radical reactions induced by OH-radical attack on cytosine-related compounds:a study by a method combininf ESR,spin trappin and HPLC. Academic PressNucleic Acid Research 18,pp.1217-1223 (Collaboration)
20.	1988	Article	Metabolic effects of 3'-deoxyadenosine (cordycepin) and 2-halo-3'-deoxyadenosine on repair of X-ray-induced potentially lethal damage in Chinese hamster V79 Cells Academic PressRadiation Research 114,pp.231-239 (Collaboration)
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■ Conference Presentations

1.	2018/11/01	ESR analysis of ROS-induced transition of electron transport chain of mitochondria (The 57th Annual Meeting of the Society of Electron Spin Science and Technology)
2.	2018/11/01	Redox potential of copper-binding prion peptide (The57th Annual Meeting of the Society of Electron Spin Science and Technology)
3.	2018/09/15	ESR analysis of ROS-induced dysfunction of electron transport chain of mitochondria (The 56th Annual Meeting of the BSJ)
4.	2018/09/15	Redox potential of copper-binding prion peptide (The 56th Annual Meeting of the BSJ)
5.	2018/06/06	Crosstalk between mitochondria and NOX2 in vitamin D3-induced differentiation in PLB- 985 myeloid cells (The 19th biennial meeting for the Society for Free Radical Research International)
6.	2018/06/06	Radiation-induced response of mitochondrial energy metabolism in tumor cells (19th Biennial meeting for the Society for Free Radical Research)
7.	2007/12	Effect of OH radicals induced by 1 MHz-ultrasound on HeLa Cells.
8.	2007/12	Reactive oxygen species-independent deformation of copper-centered proteins by 1 MHz ultrasound.
9.	2007/12	Sonochemical cleavage at photosensitive crosslinkage of caged fluorescein derivatives.
10.	2007/11	Analysis of pH-sensitivity and conformational stability in mouse prion protein by cysteine-scanning site-directed spin labeling.
11.	2007/11	Identification of Cu(II) binding site in carboxy-terminal domain of mouse PrPC: Site-directed spin labeling study
12.	2007/07	Reactive oxygen species modulate CDK4/cyclinD1 in differentiation of PLB-985 cells.
13.	1999/11	Effect of BAPTA-AM and forskolin on apoptosis and eytochrome c release in photosensitized Chinese hamster V79 cells.
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■ Academic Qualifications

1.		Faculty of Veterinary Medicine, Hokkaido University, Graduated,
2.	1990/03 Degree Acquisition	Hokkaido University, Doctor of Veterinary Science

■ Current Specialized Field

Biophysics, Radiation influence