Faculty Database - KAWANO NATSUKO

Books and Papers

Conference Presentations

Academic Qualifications

Career History

Major Subjects

Research Topics, Consignment Studies & KAKENHI Researches

Web Sites

（Last updated : 2025-04-17 11:54:06）

KAWANO NATSUKO
Department Undergraduate School , School of Agriculture

Position Professor

■ Books and Papers

1.	2025/03	Article	Comprehensive observation of histone lysine lactylation during gametogenesis of Drosophila melanogaster. Developmental dynamics : an official publication of the American Association of Anatomists (Collaboration)
2.	2025/02	Article	Complement Factor B Deficiency Is Dispensable for Female Fertility but Affects Microbiome Diversity and Complement Activity. International journal of molecular sciences 26(3) (Collaboration)
3.	2023/10	Article	CD9 protects the sperm from cytotoxic factors in the epididymis as extracellular components microPublication Biology (Collaboration)
4.	2023/06	Article	Long days restore regular estrous cyclicity in mice lacking circadian rhythms. Heliyon 9(6),pp.e16970 (Collaboration)
5.	2023/03	Article	Proteasome-Associated Proteins, PA200 and ECPAS, Are Essential for Murine Spermatogenesis Biomolecules 13(4),pp.586-586 (Collaboration)
6.	2023/03	Article	Sodium Hexametaphosphate Serves as an Inducer of Calcium Signaling Biomolecules 13(4),pp.577-577 (Collaboration)
7.	2023/01	Article	Embryonic β-Catenin Is Required for Priming of the Uterus to Implantation Laboratory Investigation 103(3),pp.100026-100026 (Collaboration)
8.	2023	Article	Identification of a putative syncytin gene in a non-rodent laboratory mammal, Suncus murinus Journal of Veterinary Medical Science (Collaboration)
9.	2022/06	Article	Extra-mitochondrial citrate synthase controls cAMP-dependent pathway during sperm acrosome reaction in mice. microPublication biology 2022 (Collaboration)
10.	2022/05	Article	Trehalose Suppresses Lysosomal Anomalies in Supporting Cells of Oocytes and Maintains Female Fertility. Nutrients 14(10) (Collaboration)
11.	2022/02	Article	Suppressive Role of Lactoferrin in Overweight-Related Female Fertility Problems 14(5),pp.938 (Collaboration)
12.	2022/01	Article	Effects of tris(1,3-dichloro-2-propyl) phosphate on epididymal sperm parameters in adult male rats. The Journal of veterinary medical science 84(1),pp.153-156 (Collaboration)
13.	2021/12	Article	Sperm acrosome status before and during fertilization in the Chinese hamster (Cricetulus griseus), and observation of oviductal vesicles and globules. Molecular reproduction and development 88(12),pp.793-804 (Collaboration)
14.	2021/11	Article	Identification of an antibacterial polypeptide in mouse seminal vesicle secretions. Journal of reproductive immunology 148,pp.103436 (Collaboration)
15.	2021/02	Article	Similar responsiveness between C57BL/6N and C57BL/6J mouse substrains to superovulation. microPublication biology (Collaboration)
16.	2020/11	Article	Suppression of Non-Random Fertilization by MHC Class I Antigens. International journal of molecular sciences 21(22),pp.8731 (Collaboration)
17.	2020/05	Article	Human Semenogelin 1 Promotes Sperm Survival in the Mouse Female Reproductive Tract International Journal of Molecular Sciences 21(11),pp.3961 (Collaboration)
18.	2019/12	Article	Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction Laboratory Investigation pp.1-13 (Collaboration)
19.	2019/09	Article	Deletion of a Seminal Gene Cluster Reinforces a Crucial Role of SVS2 in Male Fertility. International Journal of Molecular Sciences 20(18),pp.E4557 (Collaboration)
20.	2019/08	Article	Creation of CRISPR-based germline-genome-engineered mice without ex vivo handling of zygotes by i-GONAD. 14(8),pp.2452-2482 (Collaboration)
21.	2019	Article	Calaxin is required for cilia-driven determination of vertebrate laterality. Communications biology 2,pp.226 (Collaboration)
22.	2019	Article	Membrane protein CD9 is repositioned and released to enhance uterine function Laboratory Investigation 99,pp.200-209 (Collaboration)
23.	2019	Article	Microexosomes versus exosomes: Shared components but distinct structures. Regenerative therapy 11,pp.31-33 (Collaboration)
24.	2018	Book	Regulation of Sperm-Egg Fusion at the Plasma Membrane Reproductive and Developmental Strategies pp.549-568 (Collaboration)
25.	2018	Article	Autophagy-disrupted LC3 abundance leads to death of supporting cells of human oocytes Biochemistry and Biophysics Reports (15),pp.107-114 (Collaboration)
26.	2018	Article	Chemotactic behavior of egg mitochondria in response to sperm fusion in mice. Heliyon 4(11),pp.e00944 (Collaboration)
27.	2018	Article	Degradation of phosphate polymer polyP enhances lactic fermentation in mice. Genes to cells : devoted to molecular & cellular mechanisms 23(10),pp.904-914 (Collaboration)
28.	2018	Article	Membrane protein CD9 is repositioned and released to enhance uterine function Laboratory Investigation (Collaboration)
29.	2018	Article	Ubiquitin-activating enzyme E1 inhibitor PYR-41 retards sperm enlargement after fusion to the egg. Reproductive Toxicology 76,pp.71-77 (Collaboration)
30.	2017	Article	Birthweights and Down syndrome in neonates that were delivered after frozen-thawed embryo transfer: The 2007-2012 Japan Society of Obstetrics and Gynecology National Registry data in Japan 16(2),pp.228-234 (Collaboration)
31.	2017	Article	Exosomes versus microexosomes: Shared components but distinct functions Journal of Plant Research 130(3),pp.479-483 (Collaboration)
32.	2016	Article	Critical roles of seminal plasma on sperm migration in the female reproductive tract. Journal of Reproduction Engineering 18(1),pp.5-10 (Collaboration)
33.	2016	Article	Seminal vesicle proteins SVS3 and SVS4 facilitate SVS2 effect on sperm capacitation Reproduction 152(4),pp.313-321 (Collaboration)
34.	2015	Article	Breast milk stimulates growth hormone secretion in infant mice, and phosphorus insufficiency disables this ability and causes dwarfism-like symptoms Regenerative Therapy 2,pp.49-56 (Collaboration)
35.	2015	Article	Epididymal C4b-binding protein is processed and degraded during transit through the duct and is not essential for fertility Immunobiology 220(4),pp.467-475 (Collaboration)
36.	2015	Article	Seminal vesicle secretion 2 acts as a protectant of sperm sterols and prevents ectopic sperm capacitation in mice Biology of reproduction 92(1),pp.8 (Collaboration)
37.	2015	Article	Staphylococcus epidermidis is involved in a mechanism for female reproduction in mice (Collaboration)
38.	2014	Article	Absence of CD9 reduces endometrial VEGF secretion and impairs uterine repair after parturition (Collaboration)
39.	2014	Article	Mitochondrial Fission Factor Drp1 Maintains Oocyte Quality via Dynamic Rearrangement of Multiple Organelles Current Biology (Collaboration)
40.	2014	Article	Role of CD9 in Sperm Egg Fusion and Virus Induced Cell Fusion in Mammals (Collaboration)
41.	2014	Article	Seminal vesicle protein SVS2 is required for sperm survival in the uterus (Collaboration)
42.	2013	Article	Critical role of exosomes in sperm egg fusion and virus induced cell cell fusion 12(4),pp.117-126 (Collaboration)
43.	2012	Article	CD81 and CD9 work independently as extracellular components upon fusion of sperm and oocyte Biology Open 2012(1),pp.640-647 (Collaboration)
44.	2012	Article	Impairment of sperm in in vitro fertility by SOD1 deficiency (Collaboration)
45.	2011	Article	beta catenin is a molecular switch that regulates transition of cell-cell adhesion to fusion (Collaboration)
46.	2011	Article	Innate immune system still works at diapause, a physiological state of dormancy in insects (Collaboration)
47.	2011	Article	Lipid rafts: keys to sperm maturation, fertilization, and early embryogenesis (Collaboration)
48.	2011	Article	Role of CD9 in sperm-Egg fusion and its general role in fusion phenomena (Collaboration)
49.	2010	Article	Mice lacking two sperm serine proteases, ACR and PRSS21, are subfertile, but the mutant sperm are infertile in vitro (Collaboration)
50.	2010	Article	Phosphorylation of the MAPK pathway has an essential role in the acrosome reaction in miniature pig sperm (Collaboration)
51.	2010	Article	Roles of CD9 and CD9-Containing Exosomes in Sperm-Egg Membrane Fusion (Collaboration)
52.	2009	Article	Functional implications of membrane modification with semenogelins for inhibition of sperm motility in humans (Collaboration)
53.	2008	Article	Control of sperm motility and fertility: diverse factors and common mechanisms (Collaboration)
54.	2008	Article	Ganglioside GM1 mediates decapacitation effects of SVS2 on murine spermatozoa (Collaboration)
55.	2008	Article	Physiological roles of semenogelin I and zinc in sperm motility and semen coagulation on ejaculation in humans (Collaboration)
56.	2007	Article	Semen coagulating protein, SVS2, in mouse seminal plasma controls sperm fertility (Collaboration)
57.	2004	Article	Motility and penetration competence of frozen thawed miniature pig spermatozoa are substantially altered by exposure to seminal plasma before freezing (Collaboration)
58.	2004	Article	The role of calcium/calmodulin-dependent protein kinase II on the inactivation of MAP kinase and p34cdc2 kinase during fertilization and activation in pig oocytes (Collaboration)
59.	2003	Article	Luteinizing hormone receptor formation in cumulus cells surrounding porcine oocytes and its role during meiotic maturation of porcine oocytes (Collaboration)
60.	2002	Article	Delay of nuclear maturation and reduction in developmental competence of pig oocytes after mineral oil overlay of in vitro maturation media Reproduction (Collaboration)
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■ Conference Presentations

1.	2024/07/15	Complement Alternative Pathway Contributes to the Intrauterine Spermicidal Activity in Mice. (Society of the Study of Reproduction, 57th Annual meeting)
2.	2017/09/22	Critical signals of oogamous reproduction (The 88th Annual Meeting of the Zoological Society of Japan)
3.	2017/09/22	Microexosome: A fusion-promoting organelle discovered from mouse ferti lization (The 88th Annual Meeting of the Zoological Society of Japan)
4.	2017/09/15	(19th Annual Symposium on Pharmacometorics)
5.	2017/06/03	(The 58th Annual Meeting of Japan Society for Ova Resaerch)
6.	2017/06/02	(The 58th Annual Meeting Of Japan Society for Ova Resaerch)
7.	2017/06/02	(The 58th Annual Meeting of Japan Society for Ova Resaerch)
8.	2017/06/02	(The 58th Annual Meeting of Japan Society for Ova Resaerch)
9.	2017/03/29	Seminal vesicle protein SVS2 is required for sperm survival in the uterus (The 94th Annual Meeting of the Physiological Society of Japan)
10.	2016/11/17	Functional analysis of CD9 and egg exosome-mediated membrane fusion process in fertilization. (the 87th Meeting of the Zoological Society of Japan)
11.	2016/11/17	In Focus: Organelles in Sperm and Oocytes
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■ Academic Qualifications

1.	2004/04～2007/03	〔Doctorial Course〕, Graduate School, Division of Science, The University of Tokyo, Completed,
2.	2003/04～2004/03	〔Doctorial Course〕, Graduate School, Division of Biophere Sciences, Hiroshima University, Unfinished course,
3.	2001/04～2003/03	〔Master Course〕, Graduate School, Division of Biophere Sciences, Hiroshima University, Completed,
4.	1997/04～2001/03	Faculty of Applied Biological Science, Hiroshima University, Graduated,

■ Career History

1.	2019/04～	Associate Professor
2.	2015/04～2019/03	Lecturer
3.	2014/04～2015/03	Special researcher of the Japan Society for the Promotion of Science
4.	2010/04～2014/03	Special researcher of the Japan Society for the Promotion of Science
5.	2009/04～2010/03	Researcher
6.	2007/04～2009/03	Researcher
7.	2003/04～2004/03	Special researcher of the Japan Society for the Promotion of Science
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■ Research Topics, Consignment Studies & KAKENHI Researches

1.	2022/04～2026/03	Aging-dependent conversion of nutrient intake and metabolic cycles from cellular to organ levels (Key Word : )
2.	2021/07～2026/03	Mechanism of aging and healthy problems: Conversion of extracellular vesicle-forming system (Key Word : )

■ Web Sites

http://www.isc.meiji.ac.jp/~nkawano/index.html