SATO BAN    Department   Undergraduate School  , School of Agriculture    Position   Assistant Professor
Research Period	2013/04～2015/03
Research Topic	Reduction of Chondroitin sulfate chains with aging is involved in fertility in mouse preimplantation embryos
Research Type	KAKENHI Research
Consignor	Japan Society for the Promotion of Science
Research Program Type	Grant-in-Aid for Young Scientists (B)
KAKENHI Grant No.	25861517
Representative Person	SATO Ban
Details	To investigate the mechanism of MNB formation, we focused on two independent research topics. (1) The frequency of multinucleated blastomeres increases in chondroitin sulfate (CS) knockout embryos. (2) Several Age-related diseases cause by which the expression level of CS diminished with age.　We hypothesized that formation of MNB is caused by reduction of CS chains with aging.　 In this study, we revealed that CS chains are involved in abscission at the telophase in mouse preimplantation embryos.