Department   Undergraduate School  , School of Agriculture
   Position   Assistant Professor
Research Period 2013/04~2015/03
Research Topic Reduction of Chondroitin sulfate chains with aging is involved in fertility in mouse preimplantation embryos
Research Type KAKENHI Research
Consignor Japan Society for the Promotion of Science
Research Program Type Grant-in-Aid for Young Scientists (B)
KAKENHI Grant No. 25861517
Representative Person SATO Ban
Details To investigate the mechanism of MNB formation, we focused on two independent research topics. (1) The frequency of multinucleated blastomeres increases in chondroitin sulfate (CS) knockout embryos. (2) Several Age-related diseases cause by which the expression level of CS diminished with age. We hypothesized that formation of MNB is caused by reduction of CS chains with aging.  In this study, we revealed that CS chains are involved in abscission at the telophase in mouse preimplantation embryos.