SATO BAN    Department   Undergraduate School  , School of Agriculture    Position   Assistant Professor
Research Period	2014/04～2017/03
Research Topic	Involvement of the decreased chondroitin sulfate production in the presence of multinucleated blastomeres
Research Type	KAKENHI Research
Consignor	Japan Society for the Promotion of Science
Research Program Type	Grant-in-Aid for Challenging Exploratory Research
KAKENHI Grant No.	26670033
Representative Person	Kitagawa Hiroshi
Collaborative Researcher	SATO Ban
Details	Chondroitin sulfate, a long linear polysaccharide that is covalently bound to specific core proteins to form chondroitin sulfate proteoglycans, is distributed on the cell surfaces and in the extracellular matrix. To date, chondroitin sulfate proteoglycans have been reported to play important roles in physiological processes, such as cell-cell interactions, cell proliferation, differentiation, and morphogenesis. Many of the physiological roles are attributed to the chondroitin sulfate side chains. We previously reported that mutant mice completely lacking chondroitin sulfate side chains result in embryonic lethality before the 8-cell stage due to incomplete cytokinesis and that chondroitin sulfate side chains are indispensable for embryonic cell division. In this study, we showed that the decreased amount of chondroitin sulfate with age might lead to suppression of follicular maturation.