Department   Undergraduate School  , School of Agriculture
   Position   Assistant Professor
Research Period 2014/04~2017/03
Research Topic Involvement of the decreased chondroitin sulfate production in the presence of multinucleated blastomeres
Research Type KAKENHI Research
Consignor Japan Society for the Promotion of Science
Research Program Type Grant-in-Aid for Challenging Exploratory Research
KAKENHI Grant No. 26670033
Representative Person Kitagawa Hiroshi
Collaborative Researcher SATO Ban
Details Chondroitin sulfate, a long linear polysaccharide that is covalently bound to specific core proteins to form chondroitin sulfate proteoglycans, is distributed on the cell surfaces and in the extracellular matrix. To date, chondroitin sulfate proteoglycans have been reported to play important roles in physiological processes, such as cell-cell interactions, cell proliferation, differentiation, and morphogenesis. Many of the physiological roles are attributed to the chondroitin sulfate side chains. We previously reported that mutant mice completely lacking chondroitin sulfate side chains result in embryonic lethality before the 8-cell stage due to incomplete cytokinesis and that chondroitin sulfate side chains are indispensable for embryonic cell division. In this study, we showed that the decreased amount of chondroitin sulfate with age might lead to suppression of follicular maturation.