Department   Undergraduate School  , School of Agriculture
   Position   Assistant Professor
Research Period 2015/04~2017/03
Research Topic Reduction of Chondroitin sulfate chains with aging is involved in formation of multi-nucleated blastomeres in mouse
Research Type KAKENHI Research
Consignor Japan Society for the Promotion of Science
Research Program Type Grant-in-Aid for Young Scientists (B)
KAKENHI Grant No. 15K20170
Representative Person SATO Ban
Details To investigate the mechanism of MNB formation, we focused on two independent research topics. (1) The frequency of multinucleated blastomeres increases in chondroitin sulfate (CS) knockout embryos. (2) Several Age-related diseases cause by which the expression level of CS diminished with age. We hypothesized that formation of MNB is caused by reduction of CS chains with aging In this study, we revealed that CS chains moiety of CSPG decide the localization of abscission molecules in mouse preimplantation embryos by using live-cell imaging.