SATO BAN
Department Undergraduate School , School of Agriculture Position Assistant Professor |
|
Research Period | 2017/04~2020/03 |
Research Topic | The novel strategy to treat male infertility by oxidative stress |
Research Type | KAKENHI Research |
Consignor | Japan Society for the Promotion of Science |
Research Program Type | Grant-in-Aid for Scientific Research (C) |
KAKENHI Grant No. | 17K11217 |
Representative Person | SATO Ban |
Details | Although oxidative stress related to abnormal spermatogenesis in patients of male infertile, the underlying mechanisms of occurrence of male infertile is poorly understood. To investigate the mechanism of spermatogenesis involved with oxidative stress, we focused on three independent research topics. (1) Decreased activity of protein degradation by proteasome induce poor sperm motility. (2) Increment of oxidative stress observed in the patients of male infertility. We hypothesized that male infertility caused by the breakdown of oxidative stress response with hypoactivity of proteasome. In this study, we revealed that Lipin1 is a candidate for regulation of spermatogenesis with mitochondrial sheath formation. |