Department   Undergraduate School  , School of Agriculture
   Position   Assistant Professor
Research Period 2017/04~2020/03
Research Topic The novel strategy to treat male infertility by oxidative stress
Research Type KAKENHI Research
Consignor Japan Society for the Promotion of Science
Research Program Type Grant-in-Aid for Scientific Research (C)
KAKENHI Grant No. 17K11217
Representative Person SATO Ban
Details Although oxidative stress related to abnormal spermatogenesis in patients of male infertile, the underlying mechanisms of occurrence of male infertile is poorly understood. To investigate the mechanism of spermatogenesis involved with oxidative stress, we focused on three independent research topics. (1) Decreased activity of protein degradation by proteasome induce poor sperm motility. (2) Increment of oxidative stress observed in the patients of male infertility. We hypothesized that male infertility caused by the breakdown of oxidative stress response with hypoactivity of proteasome. In this study, we revealed that Lipin1 is a candidate for regulation of spermatogenesis with mitochondrial sheath formation.