NAKAMURA Takahiro    Department   Undergraduate School  , School of Agriculture    Position   Professor
Research Period	2014/04～2017/03
Research Topic	Plasticity of the environmental adaptation in mice exposed to a "Social Jet-lag" condition
Research Type	KAKENHI Research
Consignor	Japan Society for the Promotion of Science
Research Program Type	Grant-in-Aid for Scientific Research (C)
KAKENHI Grant No.	26462809
Responsibility	Collaborative Researcher
Representative Person	NAKAMURA Wataru
Collaborative Researcher	TOKUDA Isao, NAKAMURA Takahiro, TAKASU Nana
Details	Recently, the number of people showing social jet lag (the mismatch between our body’s internal clock and our daily schedules) and the serious health consequences is increasing. In the present study, we investigated the impact of a light-dark cycle that simulated weekly social jet lag. When mice are maintained under 12-h light/ 12-h dark cycles (lights on at 08:00), they show the extremely precise circadian wheel-running behavior that began within a few minutes after light-off every day. These mice were then exposed to light from 8 A.M. to 8 P.M. for 5 days (weekdays), which was followed by a shift in the exposure to light from 11 A.M. to 11 P.M. for 2 days (the weekend).Desynchronization between the environment and the biological clock (i.e., ‘‘circadian timing shift’’) has a major impact on female reproductive functions. Furthermore, normal reproductive functioning can be rescued by manipulation of environmental timing signals.