ISHIMARU YOSHIRO    Department   Undergraduate School  , School of Agriculture    Position   Professor
Research Period	2011/04～2014/03
Research Topic	Integrated molecular analysis of taste signal generation, transmission and cognition
Research Type	KAKENHI Research
Consignor	Japan Society for the Promotion of Science
Research Program Type	Grant-in-Aid for Scientific Research (A)
KAKENHI Grant No.	23248058
Responsibility	Collaborative Researcher
Representative Person	ABE Keiko
Collaborative Researcher	ISHIMARU Yoshiro, OKADA Shinji
Details	Outline of the research: For the integrated analysis of taste systems, (1) we found the target genes AnoI, Kene3, Sec61a1 that are involved in construction of electric potential of saltiness reception (type I) cell membrane; (2) PLC-beta2-WGA medaka fish analysis led to comprehensive elucidation of the taste transmission pathway from bitterness/amino acid receiving cells to the endbrain and the visualization of saltiness-receiving cell to the NST taste area in PKD1L3-WGA mice was successive; and (3) integrated expression markers in weaning mice, SNAP25, EGr-2 and Krox-20, were distinctly activated its signal in the taste area when the mice were given a solid food at the stage of weaning in comparison with the case that they were still given a liquid food. (4) we also showed that there is a relationship between the tastant quality in diet and the food intake.