ISHIMARU YOSHIRO
Department Undergraduate School , School of Agriculture Position Professor |
|
Research Period | 2013/04~2015/03 |
Research Topic | Characterization of sweet taste receiving cells in the gut and analysis of their cellular functions |
Research Type | KAKENHI Research |
Consignor | Japan Society for the Promotion of Science |
Research Program Type | Grant-in-Aid for Challenging Exploratory Research |
KAKENHI Grant No. | 25560046 |
Responsibility | Collaborative Researcher |
Representative Person | ABE Keiko |
Collaborative Researcher | ISHIMARU Yoshiro |
Details | The transcription factor Skn-1a was found to be expressed not only in taste cells but also in gut brush cells. Also, it was involved in their differentiation. Mice with deleted Skn-1a (S-KO) and wild type mice showed similar food intakes when fed on a standard diet (AIN 93G) and on a high-fat diet. Despite that, S-KO mice were significantly different from wild type mice is terms of body weight decrease, body fat reduction, insulin secretion decrease at the time of OGTT, serum ketone body elevation, and so on. This indicates that lipid metabolism is more activated in Skn-1a mice and also that their brush border cells function possibly as an energy sensor. |