ISHIMARU YOSHIRO    Department   Undergraduate School  , School of Agriculture    Position   Professor
Research Period	2014/04～2017/03
Research Topic	Peripheral Response to Tastant Signals and Central Cognition for Analysis of Their Coordination and its Application to the Science of Food for Life
Research Type	KAKENHI Research
Consignor	Japan Society for the Promotion of Science
Research Program Type	Grant-in-Aid for Scientific Research (A)
KAKENHI Grant No.	26242007
Responsibility	Collaborative Researcher
Representative Person	ABE Keiko
Collaborative Researcher	ASAKURA Tomiko, MISAKA Takumi, ISHIMARU Yoshiro
Details	We constructed Skn-1a knocked-out (S-KO) mice and found the absence of this transcription factor in the gut. The S-KO mice and wild type (WT) mice were similar in diet intake, but the former mice were distinctly lower than the latter mice in terms of body weight. While there was no difference in lipid absorption between S-KO and WT mice, the S-KO mice were characterized by a larger degree of obesity suppression at the age of 16 weeks. The S-KO mice were also characterized by the activation of hyperpressure and gastrocnemius mitochondrial copy number. Also, an oral glucose charge test showed that there was no blood glucose level difference between S-KO and WT mice, the former mice had a larger insulin secretion. This means that the lower body weight observed for S-KO mice is due to catecholamine-induced activation of lipolysis.