ISHIMARU YOSHIRO
   Department   Undergraduate School  , School of Agriculture
   Position   Professor
Research Period 2016/04~2018/03
Research Topic Obesity induced by collapsed feeding rhythm
Research Type KAKENHI Research
Consignor Japan Society for the Promotion of Science
Research Program Type Grant-in-Aid for Challenging Exploratory Research
KAKENHI Grant No. 16K12746
Responsibility Collaborative Researcher
Representative Person OIKE Hideaki
Collaborative Researcher ISHIMARU Yoshiro
Details In this study, we analyzed effects of light/dark- or feeding/fasting- pattern on body weight, energy metabolism, and circadian clocks of peripheral tissues in mice. As a result, periodic advance of light/dark cycle efficiently increased body weight gain. Under this light/dark condition, the body weight gain was correlated with decrease of circadian amplitude of respiratory quotient fluctuation and also correlated with glucose usage. It was suggested that collapse of circadian feeding rhythm due to irregular activity pattern caused suppression of lipid usage, leading to obesity.