ISHIMARU YOSHIRO
Department Undergraduate School , School of Agriculture Position Professor |
|
Research Period | 2016/04~2019/03 |
Research Topic | Physiological function of the receptor expressing intestinal tuft cells and screening of its inhibitors |
Research Type | KAKENHI Research |
Consignor | Japan Society for the Promotion of Science |
Research Program Type | Grant-in-Aid for Scientific Research (B) |
KAKENHI Grant No. | 16H04919 |
Responsibility | Representative Researcher |
Representative Person | ISHIMARU Yoshiro |
Details | To elucidate the function of the orphan receptor Gprc5c, which is expressed in intestinal tuft cells, in vivo, we generated its knockout mice by new genome editing methods, TALEN and CRISPER/Cas9 and analyzed its phenotypes. KO mice have reduced body weight. Infection experiments showed that Gprc5c may not be involved in type 2 innate immune response against nematode, Nippostrongylus brasiliensis, infection. |