サトウ　バン   SATO BAN   佐藤　伴    所属   明治大学  農学部    職種   助教
言語種別	日本語
発行・発表の年月	2012/11
形態種別	学術雑誌
査読	査読あり
標題	The human CD10 lacking an N-glycan at Asn(628) is deficient in surface expression and neutral endopeptidase activity.
執筆形態	共著(筆頭者)
掲載誌名	Biochimica et biophysica acta
掲載区分	国外
巻・号・頁	1820(11),1715-23頁
著者・共著者	Sato Ban, Katagiri Yohko U, Iijima Kazutoshi, Yamada Hiroyuki, Ito Satsuki, Kawasaki Nana, Okita Hajime, Fujimoto Junichiro, Kiyokawa Nobutaka
概要	CD10, also known as neprilysin or enkephalinase exhibiting neutral endopeptidase (NEP) activity, is expressed by B-lineage hematopoietic cells as well as a variety of cells from normal tissues. It cleaves peptides such as cytokines to act for terminating inflammatory responses. Although CD10 molecules of the human pre-B-cell line NALM-6 have 6 consensus N-glycosylation sites, three of them are known to be N-glycosylated by X-ray crystallography. N-glycosylation at Asn(628) is essential not only for NEP activities, but also for surface expression.
DOI	10.1016/j.bbagen.2012.06.017
ISSN	0006-3002
PMID	22766194