シマダ　トモヒロ   SHIMADA TOMOHIRO   島田　友裕    所属   明治大学  農学部    職種   専任准教授
言語種別	英語
発行・発表の年月	2011/10
形態種別	学術雑誌
査読	査読あり
標題	Novel roles of LeuO in transcription regulation of E. coli genome: antagonistic interplay with the universal silencer H-NS.
執筆形態	共著(筆頭者)
掲載誌名	Molecular microbiology
掲載区分	国外
巻・号・頁	82(2),pp.378-97
担当区分	筆頭著者
国際共著	国際共著
著者・共著者	Shimada Tomohiro, Bridier Arnaud, Briandet Romain, Ishihama Akira
概要	LeuO, the regulator of leucine biosynthesis operon of Escherichia coli, is involved in the regulation of as yet unspecified genes affecting the stress response and pathogenesis expression. To get insights into the regulatory role(s) of LeuO, Genomic SELEX screening has been performed to identify the whole set of its regulation targets. A total of 140 LeuO-binding sites were identified on the E. coli genome, of which as many as 133 (95%) were found to contain the binding sites of H-NS, the universal silencer of stress-response genes, supporting the concept that LeuO plays an antagonistic role with anti-silencing activity. ...
DOI	10.1111/j.1365-2958.2011.07818.x
ISSN	1365-2958
PMID	21883529