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シマダ トモヒロ
SHIMADA TOMOHIRO
島田 友裕 所属 明治大学 農学部 職種 専任准教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2014/05 |
| 形態種別 | 学術雑誌 |
| 査読 | 査読あり |
| 標題 | Roles of cell division control factor SdiA: recognition of quorum sensing signals and modulation of transcription regulation targets. |
| 執筆形態 | 共著(筆頭者) |
| 掲載誌名 | Genes to cells : devoted to molecular & cellular mechanisms |
| 掲載区分 | 国外 |
| 巻・号・頁 | 19(5),pp.405-18 |
| 担当区分 | 筆頭著者 |
| 著者・共著者 | Shimada Tomohiro, Shimada Kaori, Matsui Makoto, Kitai Yuichi, Igarashi Jun, Suga Hiroaki, Ishihama Akira |
| 概要 | In Gram-negative bacteria, N-acylhomoserine lactone (HSL) is used as a signal in cell-cell communication and quorum sensing (QS). The model prokaryote Escherichia coli lacks the system of HSL synthesis, but is capable of monitoring HSL signals in environment. Transcription factor SdiA for cell division control is believed to play a role as a HSL sensor. Using a collection of 477 species of chemically synthesized HSL analogues, we identified three synthetic signal molecules (SSMs) that bind in vitro to purified SdiA. After SELEX-chip screening of SdiA-binding DNA sequences, a striking difference was found between these SSMs in the pattern of regulation target genes on the E. coli genome. ... |
| DOI | 10.1111/gtc.12139 |
| ISSN | 1365-2443 |
| PMID | 24645791 |