シマダ　トモヒロ   SHIMADA TOMOHIRO   島田　友裕    所属   明治大学  農学部    職種   専任准教授
言語種別	英語
発行・発表の年月	2015/07
形態種別	学術雑誌
査読	査読あり
標題	Expanded roles of leucine-responsive regulatory protein in transcription regulation of the Escherichia coli genome: Genomic SELEX screening of the regulation targets.
執筆形態	共著(筆頭者)
掲載誌名	Microbial genomics
掲載区分	国外
巻・号・頁	1(1),pp.e000001
担当区分	筆頭著者,責任著者
著者・共著者	Shimada Tomohiro, Saito Natsumi, Maeda Michihisa, Tanaka Kan, Ishihama Akira
概要	Leucine-responsive regulatory protein (Lrp) is a transcriptional regulator for the genes involved in transport, biosynthesis and catabolism of amino acids in Escherichia coli. In order to identify the whole set of genes under the direct control of Lrp, we performed Genomic SELEX screening and identified a total of 314 Lrp-binding sites on the E. coli genome. As a result, the regulation target of Lrp was predicted to expand from the hitherto identified genes for amino acid metabolism to a set of novel target genes for utilization of amino acids for protein synthesis, including tRNAs, aminoacyl-tRNA synthases and rRNAs. ...
DOI	10.1099/mgen.0.000001
ISSN	2057-5858
PMID	28348809