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トムラ ヒデアキ
Tomura Hideaki
戸村 秀明 所属 明治大学 農学部 職種 専任教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2024/08 |
| 形態種別 | 学術雑誌 |
| 査読 | 査読あり |
| 標題 | Low pH modulates lipopolysaccharide-induced tumor necrosis factor-alpha expression and macropinocytotic activity in RAW264.7 cells. |
| 執筆形態 | 共著(編集/監修) |
| 掲載誌名 | Journal of receptor and signal transduction research |
| 掲載区分 | 国外 |
| 巻・号・頁 | pp.1-9 |
| 著者・共著者 | Miku Otsugu, Ayumi Mine, Izumi Uchida, Yuta Miyake, Ryo Tachihara, Kurumi Fujiwara, Ayako Ichimura, Koichi Sato, Hideaki Tomura |
| 概要 | This study investigates the impact of extracellular acidification on lipopolysaccharide-induced tumor necrosis factor-alpha (TNF-α) expression and macropinocytotic activity in RAW264.7 cells. Results show that TNF-α expression increased with decreasing extracellular pH in both un-foamed and foamed cells. Macropinocytotic activity was upregulated at pH 6.8 in un-foamed cells, but downregulated in foamed cells stimulated at low pH. Proton-sensing G protein-coupled receptors (GPCRs) were involved in the expression of TNF-α and in the macropinocytotic activity of foamed cells. In conclusion, this study reveals that extracellular acidification differently affect various inflammatory responses such as LPS-induced TNF-α expression and macropinocytotic activity of RAW264.7 cells and different proton-sensing GPCRs are involved in the different inflammatory responses. |
| DOI | 10.1080/10799893.2024.2395310 |
| ISSN | 1532-4281 |
| PMID | 39175331 |