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言語種別	日本語
発行・発表の年月	2017/12
形態種別	学術雑誌
標題	KLHL7 promotes TUT1 ubiquitination associated with nucleolar integrity: Implications for retinitis pigmentosa.
執筆形態	共著(筆頭者以外)
掲載誌名	Biochemical and biophysical research communications
掲載区分	国外
巻・号・頁	494(1-2),220-226頁
著者・共著者	Kim Jaehyun, Tsuruta Fuminori, Okajima Tomomi, Yano Sarasa, Sato Ban, Chiba Tomoki
概要	Kelch-like protein 7 (KLHL7) is a component of Cul3-based Cullin-RING ubiquitin ligase. Recent studies have revealed that mutations in klhl7 gene cause several disorders, such as retinitis pigmentosa (RP). Although KLHL7 is considered to be crucial for regulating the protein homeostasis, little is known about its biological functions. In this study, we report that KLHL7 increases terminal uridylyl transferase 1 (TUT1) ubiquitination involved in nucleolar integrity. Finally, KLHL7 increases TUT1 ubiquitination levels. Taken together, these results imply that KLHL7 is a novel regulator of nucleolus associated with TUT1 ubiquitination. Our study may provide a valuable information to elucidate a pathogenic mechanism of RP.
DOI	10.1016/j.bbrc.2017.10.049
ISSN	1090-2104
PMID	29032201