ヒラオカ　ワカコ   Hiraoka Wakako   平岡　和佳子    所属   明治大学  理工学部    職種   専任教授
言語種別	英語
発行・発表の年月	2019/09
形態種別	学術雑誌
査読	査読あり
標題	Nucleoside analogs as a radiosensitizer modulating DNA repair, cell cycle checkpoints, and apoptosis.
執筆形態	共著(筆頭者以外)
掲載誌名	Nucleosides, nucleotides & nucleic acids
掲載区分	国外
巻・号・頁	pp.1-14
著者・共著者	Yasui Hironobu, Iizuka Daisuke, Hiraoka Wakako, Kuwabara Mikinori, Matsuda Akira, Inanami Osamu
概要	The combination of low dose of radiation and an anticancer drug is a potent strategy for cancer therapy. Nucleoside analogs are known to have a radiosensitizing effects via the inhibition of DNA damage repair after irradiation. Certain types of nucleoside analogs have the inhibitory effects on RNA synthesis, but not DNA synthesis, with multiple functions in cell cycle modulation and apoptosis. In this review, the most up-to-date findings regarding radiosensitizing nucleoside analogs will be discussed, focusing especially on the mechanisms of action.
DOI	10.1080/15257770.2019.1670839
ISSN	1532-2335
PMID	31560250