ニシモリ　ヒラク   NISHIMORI HIRAKU   西森　拓    所属   明治大学研究・知財戦略機構・農場  研究・知財戦略機構    職種   特任教授
言語種別	英語
発行・発表の年月	2013
形態種別	学術雑誌
査読	査読あり
標題	Influences of excluded volume of molecules on signaling processes on the biomembrane.
執筆形態	共著(筆頭者以外)
掲載誌名	PloS one
掲載区分	国外
巻・号・頁	8(5),pp.e62218
著者・共著者	Fujii Masashi, Nishimori Hiraku, Awazu Akinori
概要	This study explores how molecular crowding on cell membranes affects biochemical signal transduction. Using a 2D model of receptors, signaling proteins, and target proteins, it shows that as target protein binding increases, signal flow (activation frequency) can follow three patterns: steadily increasing, bell-shaped, or S-shaped. Crowding causes signaling proteins to cluster around receptors, with target proteins surrounding these clusters during high signal flow. Stochastic analysis explains how excluded volume influences these behaviors, highlighting the key role of molecular crowding in membrane reactions.
DOI	10.1371/journal.pone.0062218
ISSN	1932-6203
PMID	23658714