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カワノ ナツコ
KAWANO NATSUKO
河野 菜摘子 所属 明治大学 農学部 職種 専任准教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2022/06 |
| 形態種別 | 学術雑誌 |
| 査読 | 査読あり |
| 標題 | Extra-mitochondrial citrate synthase controls cAMP-dependent pathway during sperm acrosome reaction in mice. |
| 執筆形態 | 共著(筆頭者以外) |
| 掲載誌名 | microPublication biology |
| 掲載区分 | 国外 |
| 巻・号・頁 | 2022 |
| 著者・共著者 | Kang Woojin, Katano Daiki, Kawano Natsuko, Miyado Mami, Miyado Kenji |
| 概要 | The sperm consumes adenosine triphosphate (ATP) to maintain the cellular function, viability, acrosome reaction (AR), and motility. Extra-mitochondrial citrate synthase (eCS) catalyzes citrate production in the sperm head, and thus regulates sperm function through ATP synthesis, similarly to CS. This study aimed to investigate how eCS regulates AR. Herein, acrosome-reacted (ARed) sperms were rarely detected on the zona pellucida, and spontaneous ARed sperm in eCs -deficient (KO) sperm remained at low levels even with induced capacitation. Retarded AR of eCs -KO sperm was enhanced by cyclic adenosine 3',5'-monophosphate (cAMP) treatment. In conclusion, eCS regulates AR via a cAMP-dependent pathway, which presumably contributes to sperm metabolism. |
| DOI | 10.17912/micropub.biology.000579 |
| ISSN | 2578-9430 |
| PMID | 35663411 |