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イチノセ マサシ
ICHINOSE Masashi
一之瀬 真志 所属 明治大学 経営学部 職種 専任教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2024/06 |
| 形態種別 | 学術雑誌 |
| 査読 | 査読あり |
| 標題 | Correlation of diabetic renal hypoperfusion with microvascular responses of the skeletal muscle: a rat model study using diffuse correlation spectroscopy. |
| 執筆形態 | 共著(筆頭者以外) |
| 掲載誌名 | Biomedical optics express |
| 掲載区分 | 国外 |
| 巻・号・頁 | 15(6),pp.3900-3913 |
| 著者・共著者 | Mikie Nakabayashi, Jun Tanabe, Yuji Ogura, Masashi Ichinose, Yugo Shibagaki, Atsuko Kamijo-Ikemori, Yumie Ono |
| 概要 | Using diffuse correlation spectroscopy, we assessed the renal blood flow and thigh muscle microvascular responses in a rat model of type 2 diabetes. The blood flow index at the renal surface decreased significantly with arterial clamping, cardiac extirpation, and the progression of diabetic endothelial dysfunction. Renal blood flow measured in diabetic and nondiabetic rats also showed a significant correlation with the reactive hyperemic response of the thigh muscle. These results suggest shared microcirculatory dysfunction in the kidney and skeletal muscle and support endothelial responses in the skeletal muscle as a potential noninvasive biomarker of renal hypoperfusion. |
| DOI | 10.1364/BOE.522385 |
| ISSN | 2156-7085 |
| PMID | 38867789 |