シマダ　トモヒロ   SHIMADA TOMOHIRO   島田　友裕    所属   明治大学  農学部    職種   専任准教授
言語種別	日本語
発行・発表の年月	2019
形態種別	学術雑誌
査読	査読あり
標題	Coordinated Regulation of Rsd and RMF for Simultaneous Hibernation of Transcription Apparatus and Translation Machinery in Stationary-Phase Escherichia coli.
執筆形態	共著(筆頭者以外)
掲載誌名	Frontiers in genetics
掲載区分	国外
巻・号・頁	10,1153頁
著者・共著者	Yoshida Hideji, Wada Akira, Shimada Tomohiro, Maki Yasushi, Ishihama Akira
概要	Transcription and translation in growing phase of Escherichia coli, the best-studied model prokaryote, are coupled and regulated in coordinate fashion. Accordingly, the growth rate-dependent control of the synthesis of RNA polymerase (RNAP) core enzyme (the core component of transcription apparatus) and ribosomes (the core component of translation machinery) is tightly coordinated to keep the relative level of transcription apparatus and translation machinery constant for effective and efficient utilization of resources and energy. In this review article, we overview how we found these factors and what we know about the molecular mechanisms for silencing transcription apparatus and translation machinery by these factors. In addition, we provide our recent findings of promoter-specific transcription factor (PS-TF) screening of the transcription factors involved in regulation of the rsd and rmf genes.
DOI	10.3389/fgene.2019.01153
ISSN	1664-8021
PMID	31867037