オノ　ユミエ   ONO YUMIE   小野　弓絵    所属   明治大学  理工学部    職種   専任教授
言語種別	英語
発行・発表の年月	2018/09
形態種別	学術雑誌
査読	査読あり
標題	Muscular blood flow responses as an early predictor of the severity of diabetic neuropathy at a later stage in streptozotocin-induced type I diabetic rats: a diffuse correlation spectroscopy study
執筆形態	共著(筆頭者)
掲載誌名	Biomedical Optics Express
掲載区分	国外
出版社・発行元	OSA Publishing
巻・号・頁	9(9),pp.4539-4551
著者・共著者	◎Y. Ono, K. Esaki, Y. Takahashi, M. Nakabayashi, M. Ichinose, K. J. Lee
概要	We propose a novel application of diffuse correlation spectroscopy to evaluate microvascular malfunctions of muscle tissue affected by hyperglycemia and determine their correlation with the severity of diabetic neuropathy at a later stage. Microvascular responses of the thigh muscle and the mechanical pain threshold of the hind paw of streptozotocin-induced type I diabetic rats were continuously monitored once per week for 70 days. Significantly decreased baseline blood flow and reactive hyperemia responses were observed as early as 1 week after hyperglycemia induction. The reactive hyperemia response at 2 weeks of hyperglycemia waths highly correlated with the mechanical pain threshold at 8 weeks, at which time a decreased pain threshold was statistically confirmed in hyperglycemic rats relative to controls.
researchmap用URL	https://www.osapublishing.org/boe/abstract.cfm?uri=boe-9-9-4539