カメタニ　ユキノリ   KAMETANI YUKINORI   亀谷　幸憲    所属   明治大学  理工学部    職種   専任講師
言語種別	英語
発行・発表の年月	2021/06
形態種別	学術雑誌
査読	査読あり
標題	Numerical evaluation reveals the effect of branching morphology on vessel transport properties during angiogenesis
執筆形態	共著(筆頭者以外)
掲載誌名	PLOS Computational Biology
掲載区分	国外
著者・共著者	Fatemeh Mirzapour-Shafiyi, Yukinori Kametani, Takao Hikita, Yosuke Hasegawa, Masanori Nakayama
概要	Blood flow governs transport of oxygen and nutrients into tissues. Hypoxic tissues secrete VEGFs to promote angiogenesis during development and in tissue homeostasis. Here, we take a computational approach to examine the effects of vascular branching on blood flow in the growing vasculature. First of all, we reconstruct a 3D vascular model from the 2D confocal images of the growing vasculature at postnatal day 5 (P5) mouse retina, then simulate blood flow in the vasculatures, which are obtained from the gene targeting mouse models causing hypo- or hyper-branching vascular formation. Interestingly, hyper-branching morphology attenuates effective blood flow at the angiogenic front, likely promoting tissue hypoxia. In contrast, vascular hypo-branching enhances blood supply at the angiogenic front of the growing vasculature. Our results indicate the importance of detailed flow analysis in evaluating the vascular transport properties of branching morphology of the blood vessels.