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KAMETANI YUKINORI
Department Undergraduate School , School of Science and Technology Position Senior Assistant Professor |
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| Language | English |
| Publication Date | 2021/06 |
| Type | Academic Journal |
| Peer Review | Peer reviewed |
| Title | Numerical evaluation reveals the effect of branching morphology on vessel transport properties during angiogenesis |
| Contribution Type | Co-authored (other than first author) |
| Journal | PLOS Computational Biology |
| Journal Type | Another Country |
| Author and coauthor | Fatemeh Mirzapour-Shafiyi, Yukinori Kametani, Takao Hikita, Yosuke Hasegawa, Masanori Nakayama |
| Details | Blood flow governs transport of oxygen and nutrients into tissues. Hypoxic tissues secrete VEGFs to promote angiogenesis during development and in tissue homeostasis. Here, we take a computational approach to examine the effects of vascular branching on blood flow in the growing vasculature. First of all, we reconstruct a 3D vascular model from the 2D confocal images of the growing vasculature at postnatal day 5 (P5) mouse retina, then simulate blood flow in the vasculatures, which are obtained from the gene targeting mouse models causing hypo- or hyper-branching vascular formation. Interestingly, hyper-branching morphology attenuates effective blood flow at the angiogenic front, likely promoting tissue hypoxia. In contrast, vascular hypo-branching enhances blood supply at the angiogenic front of the growing vasculature. Our results indicate the importance of detailed flow analysis in evaluating the vascular transport properties of branching morphology of the blood vessels. |