サトウ　バン   SATO BAN   佐藤　伴    所属   明治大学  農学部    職種   助教
言語種別	英語
発行・発表の年月	2008/07
形態種別	学術雑誌
標題	Functional significance of stage-specific embryonic antigens in the development of preimplantation embryos
執筆形態	共著(筆頭者以外)
掲載誌名	TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY
掲載区分	国外
出版社・発行元	GAKUSHIN PUBL CO
巻・号・頁	20(113),pp.131-139
著者・共著者	Yohko U. Katagiri, Ban Sato, Kenji Miyado, Hidenori Akutsu, Hajime Okita, Akihiro Umezawa, Junichiro Fujimoto, Nobutaka Kiyokawa
概要	In preimplantation embryos, stage-specific embryonic antigen (SSEA)-1, SSEA-3, and SSEA-4 are wellknown carbohydrate marker antigens that show a stage-specific expression. SSEA-I is usually carried by glycoproteins and/or glycolipids, while SSEA-3 and SSEA-4 are mostly carried by glycosphingolipids, which are the major constituents of raft microdomains. Biochemical analysis and confocal laser-scanning microscopic study of raft microdomains have been conducted in cultured cell lines. Here, we show the dynamic movement of SSEA-4 in the raft microdomains of preimplantation mouse embryos by immunostaining with 6E2, a novel anti-SSEA-4 monoclonal antibody, and subsequently discuss the role of raft microdomains in early embryogenesis.
ISSN	0915-7352