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SATO BAN
Department Undergraduate School , School of Agriculture Position Assistant Professor |
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| Language | English |
| Publication Date | 2008/07 |
| Type | Academic Journal |
| Title | Functional significance of stage-specific embryonic antigens in the development of preimplantation embryos |
| Contribution Type | Co-authored (other than first author) |
| Journal | TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY |
| Journal Type | Another Country |
| Publisher | GAKUSHIN PUBL CO |
| Volume, Issue, Page | 20(113),pp.131-139 |
| Author and coauthor | Yohko U. Katagiri, Ban Sato, Kenji Miyado, Hidenori Akutsu, Hajime Okita, Akihiro Umezawa, Junichiro Fujimoto, Nobutaka Kiyokawa |
| Details | In preimplantation embryos, stage-specific embryonic antigen (SSEA)-1, SSEA-3, and SSEA-4 are wellknown carbohydrate marker antigens that show a stage-specific expression. SSEA-I is usually carried by glycoproteins and/or glycolipids, while SSEA-3 and SSEA-4 are mostly carried by glycosphingolipids, which are the major constituents of raft microdomains. Biochemical analysis and confocal laser-scanning microscopic study of raft microdomains have been conducted in cultured cell lines. Here, we show the dynamic movement of SSEA-4 in the raft microdomains of preimplantation mouse embryos by immunostaining with 6E2, a novel anti-SSEA-4 monoclonal antibody, and subsequently discuss the role of raft microdomains in early embryogenesis. |
| ISSN | 0915-7352 |