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ONO YUMIE
Department Undergraduate School , School of Science and Technology Position Professor |
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| Language | English |
| Publication Date | 2018/09 |
| Type | Academic Journal |
| Peer Review | Peer reviewed |
| Title | Muscular blood flow responses as an early predictor of the severity of diabetic neuropathy at a later stage in streptozotocin-induced type I diabetic rats: a diffuse correlation spectroscopy study |
| Contribution Type | Co-authored (first author) |
| Journal | Biomedical Optics Express |
| Journal Type | Another Country |
| Publisher | OSA Publishing |
| Volume, Issue, Page | 9(9),pp.4539-4551 |
| Author and coauthor | ◎Y. Ono, K. Esaki, Y. Takahashi, M. Nakabayashi, M. Ichinose, K. J. Lee |
| Details | We propose a novel application of diffuse correlation spectroscopy to evaluate microvascular malfunctions of muscle tissue affected by hyperglycemia and determine their correlation with the severity of diabetic neuropathy at a later stage. Microvascular responses of the thigh muscle and the mechanical pain threshold of the hind paw of streptozotocin-induced type I diabetic rats were continuously monitored once per week for 70 days. Significantly decreased baseline blood flow and reactive hyperemia responses were observed as early as 1 week after hyperglycemia induction. The reactive hyperemia response at 2 weeks of hyperglycemia waths highly correlated with the mechanical pain threshold at 8 weeks, at which time a decreased pain threshold was statistically confirmed in hyperglycemic rats relative to controls. |
| URL for researchmap | https://www.osapublishing.org/boe/abstract.cfm?uri=boe-9-9-4539 |