Department   Undergraduate School  , School of Science and Technology
   Position   Professor
Language English
Publication Date 2018/09
Type Academic Journal
Peer Review Peer reviewed
Title Muscular blood flow responses as an early predictor of the severity of diabetic neuropathy at a later stage in streptozotocin-induced type I diabetic rats: a diffuse correlation spectroscopy study
Contribution Type Co-authored (first author)
Journal Biomedical Optics Express
Journal TypeAnother Country
Publisher OSA Publishing
Volume, Issue, Page 9(9),pp.4539-4551
Author and coauthor Y. Ono, K. Esaki, Y. Takahashi, M. Nakabayashi, M. Ichinose, K. J. Lee
Details We propose a novel application of diffuse correlation spectroscopy to evaluate microvascular malfunctions of muscle tissue affected by hyperglycemia and determine their correlation with the severity of diabetic neuropathy at a later stage. Microvascular responses of the thigh muscle and the mechanical pain threshold of the hind paw of streptozotocin-induced type I diabetic rats were continuously monitored once per week for 70 days. Significantly decreased baseline blood flow and reactive hyperemia responses were observed as early as 1 week after hyperglycemia induction. The reactive hyperemia response at 2 weeks of hyperglycemia waths highly correlated with the mechanical pain threshold at 8 weeks, at which time a decreased pain threshold was statistically confirmed in hyperglycemic rats relative to controls.
URL for researchmap https://www.osapublishing.org/boe/abstract.cfm?uri=boe-9-9-4539