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KAWANO NATSUKO
Department Undergraduate School , School of Agriculture Position Associate Professor |
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| Language | English |
| Publication Date | 2022/06 |
| Type | Academic Journal |
| Peer Review | Peer reviewed |
| Title | Extra-mitochondrial citrate synthase controls cAMP-dependent pathway during sperm acrosome reaction in mice. |
| Contribution Type | Co-authored (other than first author) |
| Journal | microPublication biology |
| Journal Type | Another Country |
| Volume, Issue, Page | 2022 |
| Author and coauthor | Kang Woojin, Katano Daiki, Kawano Natsuko, Miyado Mami, Miyado Kenji |
| Details | The sperm consumes adenosine triphosphate (ATP) to maintain the cellular function, viability, acrosome reaction (AR), and motility. Extra-mitochondrial citrate synthase (eCS) catalyzes citrate production in the sperm head, and thus regulates sperm function through ATP synthesis, similarly to CS. This study aimed to investigate how eCS regulates AR. Herein, acrosome-reacted (ARed) sperms were rarely detected on the zona pellucida, and spontaneous ARed sperm in eCs -deficient (KO) sperm remained at low levels even with induced capacitation. Retarded AR of eCs -KO sperm was enhanced by cyclic adenosine 3',5'-monophosphate (cAMP) treatment. In conclusion, eCS regulates AR via a cAMP-dependent pathway, which presumably contributes to sperm metabolism. |
| DOI | 10.17912/micropub.biology.000579 |
| ISSN | 2578-9430 |
| PMID | 35663411 |