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Hiraoka Wakako
Department Undergraduate School , School of Science and Technology Position Professor |
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| Language | English |
| Publication Date | 2019/09 |
| Type | Academic Journal |
| Peer Review | Peer reviewed |
| Title | Nucleoside analogs as a radiosensitizer modulating DNA repair, cell cycle checkpoints, and apoptosis. |
| Contribution Type | Co-authored (other than first author) |
| Journal | Nucleosides, nucleotides & nucleic acids |
| Journal Type | Another Country |
| Volume, Issue, Page | pp.1-14 |
| Author and coauthor | Yasui Hironobu, Iizuka Daisuke, Hiraoka Wakako, Kuwabara Mikinori, Matsuda Akira, Inanami Osamu |
| Details | The combination of low dose of radiation and an anticancer drug is a potent strategy for cancer therapy. Nucleoside analogs are known to have a radiosensitizing effects via the inhibition of DNA damage repair after irradiation. Certain types of nucleoside analogs have the inhibitory effects on RNA synthesis, but not DNA synthesis, with multiple functions in cell cycle modulation and apoptosis. In this review, the most up-to-date findings regarding radiosensitizing nucleoside analogs will be discussed, focusing especially on the mechanisms of action. |
| DOI | 10.1080/15257770.2019.1670839 |
| ISSN | 1532-2335 |
| PMID | 31560250 |