Faculty Database - KUSHIRO Tetsuo

Books and Papers

Conference Presentations

Academic Qualifications

Career History

Major Subjects

researchmap Researcher Code

KAKENHI Researcher Number

（Last updated : 2021-08-11 20:25:12）

KUSHIRO Tetsuo
Department Undergraduate School , School of Agriculture

Position Professor

■ Books and Papers

1.	2021/06	Article	Two triterpene synthases from Imperata cylindrica catalyzing the formation of a pair of diastereoisomers through boat or chair cyclization ChemBioChem 22(11),pp.1992-2001 (Collaboration)
2.	2021/05	Article	Synthesis of aminoacylated ergosterols: A new lipid component of fungi Steroids 169,pp.108823 (Collaboration)
3.	2020/09	Article	Plant-specific domains and fragmented sequences imply non-canonical functions in plant aminoacyl-tRNA synthetases. Genes 11,pp.1056 (Collaboration)
4.	2020/06	Article	RNA-dependent sterol aspartylation in fungi. Proc. Natl. Acad. Sci. USA 117,pp.14948-14957 (Collaboration)
5.	2019/12	Article	Allylic hydroxylation of triterpenoids by a plant cytochrome P450 triggers key chemical transformations that produce a variety of bitter compounds. Journal of Biological Chemistry 294,pp.18662-18673 (Collaboration)
6.	2019/07	Article	Mechanism of action of prethioviridamide, an anticancer ribosomally synthesized and post-translationally modified peptide with a polythioamide structure. ACS Chemical Biology 14,pp.1819-1828 (Collaboration)
7.	2018	Article	FPX is a Novel Chemical Inducer that Promotes Callus Formation and Shoot Regeneration in Plants. Plant Cell Physiol. 59(8),pp.1555-1567 (Collaboration)
8.	2018	Article	Identification of triterpene biosynthetic genes from Momordica charantia using RNA-seq analysis. Biosci. Biotechnol. Biochem. (Collaboration)
9.	2017	Article	A quantitative shRNA screen identifies ATP1A1 as a gene that regulates cytotoxicity by aurilide B. Sci. Rep. 7,pp.2002 (Collaboration)
10.	2017	Article	Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis. Nat Commun. 8,pp.1644 (Collaboration)
11.	2017	Article	Identification of serratane synthase gene from the fern Lycopodium clavatum. Org. Lett. 19,pp.496-499 (Collaboration)
12.	2016	Article	A draft genome of the brown alga, Cladosiphon okamuranus, S-strain: a platform for future studies of 'mozuku' biology. DNA Res. 23,pp.561-570 (Collaboration)
13.	2016	Article	Highly sprouting-tolerant wheat grain exhibits extreme dormancy and cold imbibition-resistant accumulation of abscisic acid. Plant Cell Physiol. 57,pp.715-732 (Collaboration)
14.	2016	Article	Onocerin biosynthesis requires two highly dedicated triterpene cyclases in a fern Lycopodium clavatum. ChemBioChem 17,pp.288-290 (Collaboration)
15.	2015	Article	Control of the 1,2-rearrangement process by oxidosqualene cyclases during triterpene biosynthesis. Org. Biomol. Chem. 13,pp.7331-7336 (Collaboration)
16.	2012	Book	Reconstitution of a secondary metabolite biosynthetic pathway in a heterologous fungal host. Methods Mol Biol. 944,pp.175-182 (Collaboration)
17.	2012	Article	Benzophenone synthase from Garcinia mangostana L. pericarps. Phytochemistry 77,pp.60-69 (Collaboration)
18.	2012	Article	Identification of a key prenyltransferase involved in biosynthesis of the most abundant fungal meroterpenoids derived from 3,5-dimethylorsellinic acid. ChemBioChem 13,pp.1132-1135 (Collaboration)
19.	2012	Article	Terretonin biosynthesis requires methylation as essential step for cyclization. ChemBioChem 13,pp.1738-1741 (Collaboration)
20.	2011	Article	ABA 9'-hydroxylation is catalyzed by CYP707A in Arabidopsis. Phytochemistry 72,pp.717-722 (Collaboration)
21.	2011	Article	Linking genotype and phenotype of Saccharomyces cerevisiae strains reveals metabolic engineering targets and leads to triterpene hyper-producers. PLoS One 6,pp.e14763 (Collaboration)
22.	2010	Book	Triterpenes Comprehensive Natural Products Chemistry II 1,pp.673-708 (Collaboration)
23.	2010	Article	Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase. Biochem. Biophys. Res. Commun (391),pp.899-902 (Collaboration)
24.	2010	Article	Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases Nature Chemistry 2(10),pp.858-864 (Collaboration)
25.	2009	Book	Enzymatic synthesis of cyclic triterpenes Pentacyclic Triterpens as Promising Agents in Cancer (Collaboration)
26.	2009	Article	Biosynthesis of steroidal antibiotic fusidanes: Functional analysis of oxidosqualene cyclase and subsequent tailoring enzymes from Aspergillus fumigatus J. Am. Chem. Soc. 131,pp.6402-6411 (Collaboration)
27.	2008	Article	Biosynthesis of baccharis oxide, a triterpene with a 3,10-oxide bridge in the A-ring. Org. Lett. 10(21),pp.5071-5074 (Collaboration)
28.	2008	Article	Phytochrome- and gibberellin-mediated regulation of abscisic acid metabolism during germination of photoblastic lettuce seeds. Plant Physiol. 146,pp.1386-1396 (Collaboration)
29.	2007	Article	Ethylene promotes submergence-induced expression of OsABA8ox1, a gene that encodes ABA 8'-hydroxylase in rice. Plant Cell Physiol. 48,pp.287-298 (Collaboration)
30.	2006	Article	A plant growth retardant, uniconazole, is a potent inhibitor of ABA catabolism in Arabidopsis. Biosci. Biotechnol. Biochem. 70(7),pp.1731-1739 (Collaboration)
31.	2006	Article	CYP707A1 and CYP707A2, which encode abscisic acid 8'-hydroxylases, are indispensable for proper control of seed dormancy and germination in Arabidopsis. Plant Physiol. 141,pp.97-107 (Collaboration)
32.	2006	Article	CYP707A3, a major ABA 8'-hydroxylase involved in dehydration and rehydration response in Arabidopsis thaliana. Plant J. 46,pp.171-182 (Collaboration)
33.	2006	Article	Dammarenediol-II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng. FEBS Lett. 580,pp.5143-5149 (Collaboration)
34.	2006	Article	Dwarfism and cytochrome P450-mediated C-6 oxidation of plant steroid hormones. Biochem. Soc. Trans. 34,pp.1199-1201 (Collaboration)
35.	2006	Article	Field studies on the regulation of abscisic acid content and germinability during grain development of barley: molecular and chemical analysis of pre-harvest sprouting. J. Exp. Bot. 57,pp.2421-2434 (Collaboration)
36.	2006	Article	Identification of β-amyrin and sophoradiol 24-hydroxylase by expressed sequence tag mining and functional expression assay. FEBS J. 273,pp.948-959 (Collaboration)
37.	2006	Article	Lanosterol synthase in dicotyledonous plants. Plant Cell Physiol. 47,pp.565-571 (Collaboration)
38.	2006	Article	The stereochemical course in water addition during LUP1 catalyzed triterpene cyclization. Org. Lett. 8,pp.5589-5592 (Collaboration)
39.	2005	Article	The last reaction producing brassinolide is catalyzed by cytochrome P-450s, CYP85A3 in tomato and CYP85A2 in Arabidopsis J. Biol. Chem. 280,pp.17873-17879 (Collaboration)
40.	2004	Article	The Arabidopsis Cytochrome P450 CYP707A Encodes ABA 8'-Hydroxylases: Key Enzymes in ABA Catabolism EMBO J. 23,pp.1647-1656 (Collaboration)
41.	2003	Article	Functional Genomics Approach to the Study of Triterpene Biosynthesis Pure Appl. Chem. 75,pp.369-374 (Collaboration)
42.	2003	Article	The Key to Signaling Nature 422,pp.122 (Collaboration)
43.	2002	Article	Trbp111 Selectively Binds a Nonconvalently Assembled tRNA-like Structure Proc. Natl. Acad. Sci. USA 99,pp.16631-16635 (Collaboration)
44.	2001	Article	Cloning and Characterization of a cDNA Encoding beta-Amyrin Synthase Involved in Glycyrrhizin and Soyasaponin Biosyntheses in Licorice Biol. Pharm. Bull. 24,pp.912-916 (Collaboration)
45.	2001	Article	Molecular Cloning and Characterization of Isomultiflorenol Synthase, a New Triterpene Synthase from Luffa cylindrica, Involved in Biosynthesis of Bryonolic Acid. Eur. J. Biochem. 268,pp.6311-6317 (Collaboration)
46.	2000	Article	A Novel Multifunctional Triterpene Synthase from Arabidopsis thaliana Tetrahedron Lett. 41,pp.7705-7710 (Collaboration)
47.	2000	Article	Molecular Cloning and Characterization of a cDNA for Glycyrrhiza glabra Cycloartenol Synthase Biol. Pharm. Bull. 23,pp.231-234 (Collaboration)
48.	2000	Article	Molecular Cloning and Functional Expression of Triterpene Synthases from Pea (Pisum sativum); New α-Amyrin Producing Enzyme is a Multifunctional Triterpene Synthase Eur. J. Biochem. 267,pp.3453-3460 (Collaboration)
49.	2000	Article	Mutational Studies on Triterpene Synthases. Engineering Lupeol Synthase into β-Amyrin Synthase J. Am. Chem. Soc. 122,pp.6816-6824 (Collaboration)
50.	1999	Article	Biosynthesis of 20-Hydroxyecdysone in Ajuga Hairy Roots: Fate of 6α- and 6β-Hydrogens of Lathosterol Bioorg. Med. Chem. 7,pp.2925-2930 (Collaboration)
51.	1999	Article	Chimeric Triterpene Synthase. A Possible Model for Multifunctional Triterpene Synthase J. Am. Chem. Soc. 121,pp.1208-1216 (Collaboration)
52.	1999	Article	Cryptic Regiospecificity in Deprotonation Step of Triterpene Biosynthesis Catalyzed by New Members of Lupeol Synthase Tetrahedron Lett. 40,pp.5553-5556 (Collaboration)
53.	1999	Article	Two Branches of the Lupeol Synthase Gene in the Molecular Evolution of Plant Oxidosqualene Cyclases Eur. J. Biochem. 266,pp.302-307 (Collaboration)
54.	1998	Book	Molecular Cloning of Oxidosqualene Cyclase cDNA from Panax ginseng: The Isogene that Encodes β-Amyrin Synthase. Towards Natural Medicine Research in the 21st Century, Excerpta Medica International Congress Series 1157 pp.421-427 (Collaboration)
55.	1998	Article	β-Amyrin Synthase Cloning of Oxidosqualene Cyclase that Catalyzes the Formation of the Most Popular Triterpene among Higher Plants Eur. J. Biochem. 256,pp.238-244 (Collaboration)
56.	1997	Article	Biosynthesis of 20-Hydroxyecdysone in Ajuga Hairy Roots: Hydrogen Migration from C-6 to C-5 during cis-A/B Ring Formation Tetrahedron Lett. 38,pp.2697-2700 (Collaboration)
57.	1997	Article	In vitro Conversion of 2,3-Oxidosqualene into Dammarenediol by Panax ginseng Microsomes Biol. Pharm. Bull. 20,pp.292-294 (Collaboration)
58.	1996	Article	Biosynthesis of 24β-Alkyl-⊿²⁵-Sterols in Hairy Roots of Ajuga reptans var. atropurpurea Phytochemistry 41,pp.1057-1064 (Collaboration)
59.	1994	Article	3β-Hydroxy-5β-cholest-7-en-6-one as an Intermediate of 20-Hydroxyecdysone Biosynthesis in a Hairy Root Culture of Ajuga reptans var. atropurpurea J. Chem. Soc. Chem. Commun. 1994,pp.1761-1762 (Collaboration)
60.	1994	Article	Incorporation of Acetate and Cholesterol into 20-Hydroxyecdysone by Hairy Root Clone of Ajuga reptans var. atropurpurea Phytochemistry 36,pp.907-10 (Collaboration)
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■ Conference Presentations

1.	2018/09/24	Functional analysis of plant double-length tyrosyl-tRNA synthetase from Arabidopsis thaliana. (27th tRNA conference)
2.	2017/11/01	Arabidopsis histidyl-tRNA synthetase with an appended domain bestowed anthocyanin and lignin production upon overexpression in plants. (IUBMB Focused Meeting on the Aminoacyl-tRNA Synthetases.)
3.	2009/02/03	Biosynthesis of fungal meroterpenoids: a rich source of promising drug candidates. (The eighth NRCT-JSPS Joint Seminar)
4.	2008/06/26	Functional analysis of fungal meroterpenoid gene cluster (7th US-Japan seminar on the biosynthesis of natural products)

■ Academic Qualifications

1.	1995/04～1998/03	〔Doctorial Course〕, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Completed,
2.	1993/04～1995/03	〔Master Course〕, Graduate School, Division of Natural Science, Tokyo Institute of Technology, Completed,
3.	1989/04～1993/03	Department of Chemistry, Faculty of Science, Tokyo Institute of Technology, Graduated,

■ Career History

1.	2020/04～	Meiji University School of Agriculture Professor
2.	2010/04～2020/03	Meiji University School of Agriculture Associate Professor
3.	2000/09～2002	Scripps Research Institute Research Associate

■ researchmap Researcher Code

6000024120

■ KAKENHI Researcher Number

80373299