Faculty Database - NAKAMURA Takahiro

■ Books and Papers

1.	2024/02	Article	Diurnal Variation of Brain Activity in the Human Suprachiasmatic Nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience 44(8) (Collaboration)
2.	2023/08	Article	In vivo recording of suprachiasmatic nucleus dynamics reveals a dominant role of arginine vasopressin neurons in circadian pacesetting. PLoS biology 21(8),pp.e3002281 (Collaboration)
3.	2023/06	Article	Long days restore regular estrous cyclicity in mice lacking circadian rhythms. Heliyon 9(6),pp.e16970 (Collaboration)
4.	2023	Article	Circadian rhythm of PERIOD2::LUCIFERASE expression in the trigeminal ganglion of mice. Frontiers in neuroscience 17,pp.1142785 (Collaboration)
5.	2022/04	Article	Oak extracts modulate circadian rhythms of clock gene expression in vitro and wheel-running activity in mice Sleep and Biological Rhythms (Collaboration)
6.	2022/02	Article	Secretin receptor-deficient mice exhibit robust food anticipatory activity. Neuroscience letters 772,pp.136462 (Collaboration)
7.	2021	Article	Diurnal Variation in Trigeminal Pain Sensitivity in Mice. Frontiers in neuroscience 15,pp.703440-703440 (Collaboration)
8.	2021	Article	Editorial: Development of Circadian Clock Functions. Frontiers in neuroscience 15,pp.735007-735007 (Collaboration)
9.	2021/11	Article	Chronic methamphetamine uncovers a circadian rhythm in multiple-unit neural activity in the dorsal striatum which is independent of the suprachiasmatic nucleus. Neurobiology of sleep and circadian rhythms 11,pp.100070 (Collaboration)
10.	2021/05	Article	Circadian clock regulates tear secretion in the lacrimal gland. Experimental eye research 206,pp.108524 (Collaboration)
11.	2021/02	Article	GABA from vasopressin neurons regulates the time at which suprachiasmatic nucleus molecular clocks enable circadian behavior. Proceedings of the National Academy of Sciences of the United States of America 118(6) (Collaboration)
12.	2021	Article	Diurnal Variation in Trigeminal Pain Sensitivity in Mice. Frontiers in neuroscience 15,pp.703440 (Collaboration)
13.	2021	Article	Editorial: Development of Circadian Clock Functions. Frontiers in neuroscience 15,pp.735007 (Collaboration)
14.	2021	Article	Electrophysiological Approaches to Studying the Suprachiasmatic Nucleus. Methods in molecular biology (Clifton, N.J.) 2130,pp.303-324 (Collaboration)
15.	2020/10	Article	Modeling circadian regulation of ovulation timing: age-related disruption of estrous cyclicity. Scientific reports 10(1),pp.16767 (Collaboration)
16.	2020	Article	Reciprocal Expression Patterns of Placental Leucine Aminopeptidase/Insulin-Regulated Aminopeptidase and Vasopressin in the Murine Brain. Frontiers in molecular biosciences 7,pp.168 (Collaboration)
17.	2019/09	Article	Effects of testosterone on circadian rhythmicity in old mice. The journal of physiological sciences : JPS 69(5),pp.791-798 (Collaboration)
18.	2019/09	Article	Suppression of Blue Light at Night Ameliorates Metabolic Abnormalities by Controlling Circadian Rhythms. Investigative ophthalmology & visual science 60(12),pp.3786-3793 (Collaboration)
19.	2019/02	Article	Acute-phase protein-like properties of endoplasmic reticulum aminopeptidase 1. J Biochem. 165(2),pp.159-165 (Collaboration)
20.	2018/08	Article	Photic phase-response curves for cycling female mice Horm Behav 105,pp.41-46 (Collaboration)
21.	2018/06	Article	Contribution of the exosome-associated form of secreted endoplasmic reticulum aminopeptidase 1 to exosome-mediated macrophage activation. Biochim Biophys Acta. 1865(6),pp.874-888 (Collaboration)
22.	2018/07	Article	The central clock controls the daily rhythm of Aqp5 expression in salivary glands J Physiol Sci. 68(4),pp.377-385 (Collaboration)
23.	2016/09	Article	The suprachiasmatic nucleus: age-related decline in biological rhythms J Physiol Sci. 66(5),pp.367-374 (Collaboration)
24.	2016/01	Article	A Single Neonatal Injection of Ethinyl Estradiol Impairs Passive Avoidance Learning and Reduces Expression of Estrogen Receptor α in the Hippocampus and Cortex of Adult Female Rats. PLoS One 11(1),pp.e0146136 (Collaboration)
25.	2016/01	Article	Cryptochrome-dependent circadian periods in the arcuate nucleus. Neurosci Lett. 610,pp.123-128 (Collaboration)
26.	2015/09	Article	Age-Related Changes in the Circadian System Unmasked by Constant Conditions eNeuro 2(4) (Collaboration)
27.	2015/09	Article	Recovery from Age-Related Infertility under Environmental Light-Dark Cycles Adjusted to the Intrinsic Circadian Period. Cell Reports 12(9),pp.1407-1413 (Collaboration)
28.	2015/06	Article	Substrate-dependent nitric oxide synthesis by secreted endoplasmic reticulum aminopeptidase 1 in macrophages Journal of Biochemistry 157(6),pp.439-449 (Collaboration)
29.	2014/05	Article	TLR-Mediated Secretion of Endoplasmic Reticulum Aminopeptidase 1 from Macrophages. Journal of immunology (Baltimore, Md. : 1950) 192,pp.4443-4452 (Collaboration)
30.	2012/10	Article	Neural Circuits Underlying Circadian Oscillations in Mammals: Clocks in a Dish Isolated Central Nervous System Circuits; Neuromethods 73,pp.183-210 (Collaboration)
31.	2012/10	Article	Effects of age-related dopaminergic neuron loss in the substantia nigra on the circadian rhythms of locomotor activity in mice. Neuroscience research 74(3-4),pp.210-215 (Collaboration)
32.	2011/07	Article	Age-related decline in circadian output. The Journal of neuroscience : the official journal of the Society for Neuroscience 31(28),pp.10201-10205 (Collaboration)
33.	2011	Article	Reduced light response of neuronal firing activity in the suprachiasmatic nucleus and optic nerve of cryptochrome-deficient mice. PloS one 6,pp.e28726 (Collaboration)
34.	2011/06	Article	Effects of vasoactive intestinal peptide genotype on circadian gene expression in the suprachiasmatic nucleus and peripheral organs. Journal of biological rhythms 26,pp.200-209 (Collaboration)
35.	2010/03	Article	The role of the neuropeptides PACAP and VIP in the photic regulation of gene expression in the suprachiasmatic nucleus. The European journal of neuroscience 31,pp.864-875 (Collaboration)
36.	2010/03	Article	Influence of the estrous cycle on clock gene expression in reproductive tissues: effects of fluctuating ovarian steroid hormone levels. Steroids 75(3),pp.203-212 (Collaboration)
37.	2008/11	Article	Estrogen directly modulates circadian rhythms of PER2 expression in the uterus. American journal of physiology. Endocrinology and metabolism 295,pp.E1025-31 (Collaboration)
38.	2008/03	Article	In vivo monitoring of circadian timing in freely moving mice. Current biology : CB 18,pp.381-385 (Collaboration)
39.	2007/03	Article	Differential response of type 2 deiodinase gene expression to photoperiod between photoperiodic Fischer 344 and nonphotoperiodic Wistar rats. American journal of physiology. Regulatory, integrative and comparative physiology 292,pp.R1315-9 (Collaboration)
40.	2006/04	Article	Peripheral clock gene expression in CS mice with bimodal locomotor rhythms. Neuroscience research 54(4),pp.295-301 (Collaboration)
41.	2006	Article	Effects of p-nonylphenol and 4-tert-octylphenol on the anterior pituitary functions in adult ovariectomized rats. Neuroendocrinology 84,pp.14-20 (Collaboration)
42.	2005/12	Article	Estrogen differentially regulates expression of Per1 and Per2 genes between central and peripheral clocks and between reproductive and nonreproductive tissues in female rats. Journal of neuroscience research 82,pp.622-630 (Collaboration)
43.	2005/04	Article	Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal. The Journal of biological chemistry 280(14),pp.13272-13278 (Collaboration)
44.	2004/11	Article	Light response of the neuronal firing activity in the suprachiasmatic nucleus of mice. Neuroscience letters 371,pp.244-248 (Collaboration)
45.	2004/02	Article	p-Nonylphenol, 4-tert-octylphenol and bisphenol A increase the expression of progesterone receptor mRNA in the frontal cortex of adult ovariectomized rats. Journal of neuroendocrinology 16,pp.99-104 (Collaboration)
46.	2002	Article	Gonadotropin-releasing hormone (GnRH) surge generator in female rats. Progress in brain research 141,pp.165-173 (Collaboration)
47.	2002	Article	Differential regulation of pituitary adenylate cyclase-activating peptide receptor variants in the rat suprachiasmatic nucleus. Neuroscience 110,pp.301-308 (Collaboration)
48.	2001/11	Article	Effect of estrogen on the expression of Cry1 and Cry2 mRNAs in the suprachiasmatic nucleus of female rats. Neuroscience research 41(3),pp.251-255 (Collaboration)
49.	2001/09	Article	Circadian and photic regulation of cryptochrome mRNAs in the rat pineal gland. Neuroscience research 41(1),pp.25-32 (Collaboration)
50.	2001/08	Article	Effects of estrogen and progesterone on the expression of connexin-36 mRNA in the suprachiasmatic nucleus of female rats. Neuroscience letters 309,pp.37-40 (Collaboration)
51.	2015/05	Article	Effects of ovarian steroids on circadian rhythms The Autonomic Nervous System 52(1),pp.7-12 (Single)
52.	2013/04	Article	Age-related Decline in the Circadian Clock Anti-aging medicine pp.222-230 (Collaboration)
53.	2011/03	Article	Biological rhythm and chronopharmacology: perspective for chronotherapy WIAS research bulletin pp.57-66 (Collaboration)
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■ Conference Presentations

1.	2019/12/09	The circadian clock in mammals (ICMMA2019 International Conference on "Spatio-temporal patterns on various levels of the hierarchy of life")
2.	2018/10/19	Testosterone replacement exacerbates the age-related decline in circadian rhythmicity (International Symposium on Biological Rhythms)
3.	2018/07/12	Effects of the isolation of suprachiasmatic nucleus on circadian rhythmicity (Asian Forum on Chronobiology in 2018 (AFC/ASRS/JSSR Joint Symposium 2: Circadian Pacemaker and Sleep-Wake cycle))
4.	2018/05/12	Effects of the isolation of suprachiasmatic nucleus on circadian rhythmicity (SRBR meeting 2018)
5.	2015/09/05	Neural connections originating in the suprachiasmatic nucleus are necessary for estrous cyclicity (Asian Forum on Chronobiology in 2015)
6.	2015/03/23	Aging Dissociates Circadian PER2 Oscillations of Individual Cells in the Suprachiasmatic Clock
7.	2014/11/07	Aging Affects Circadian PER2 Oscillation of Individual Cell in the Suprachiasmatic Clock
8.	2013/11	DNA microarray analysis for discovering age-related molecules in the SCN
9.	2012/05/19	Role of the dopaminergic neurons present in the substantia nigra in age-related decline in circadian rhythmicity (13th Biennial Meeting Society for Research on Biological Rhythms)
10.	2012/03	The neural mechanisms of age-related decline in circadian rhythmicity: The role of dopaminergic neuron in the substantia nigra
11.	2009/10	Regulation of Circadian Period by Vasoactive Intestinal Peptide (39th annual meeting of Society for Neuroscience)
12.	2009/06	Effect of ovarian steroid hormones on circadian rhythms of clock gene expression (16th International Congress of Comparative Endocrinology)
13.	2002/09	Menstrual variations in circadian rhythm of sleep and melatonin (5th Scientific Congress of the Federation of Asian and Oceanian Physiological Societies)
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■ Academic Qualifications

1.	2005/03/25 Degree Acquisition	Nagoya University,
2.	2002/04～2005/03	〔Doctorial Course〕, Graduate School of Agricultural Sciences, Nagoya University, Completed,
3.	2000/04～2002/03	〔Master Course〕, Graduate School, Division of Medicine, Yokohama City University, Completed,

■ Career History

1.	2022/04～	Meiji University School of agriculture
2.	2017/04～2022/03	Associate Professor
3.	2014/04～2019/03	Part-time researcher for university or other academic organization

■ Teaching Activities

● Efforts to Improve Educational Contents and Method (Including Teaching Evaluation)
1.	2022/10/01～2023/01/31	Evaluating research: How well did the Nobel committee predict research importance?

■ Major Subjects

Department of Life Sciences

■ Academic Associations Membership

1.	2012/05～	Society for Research on Biological Rhythms
2.	2011/03～	PHYSIOLOGICAL SOCIETY OF JAPAN
3.	2008/10～	Society for Neuroscience
4.	2000/10～	JAPANESE SOCIETY FOR CHRONOBIOLOGY

■ Certificates and Licenses

1.

2017/01/01

Physiology Educator accredited by Physiological Society of Japan

■ Social Activities

1.	2024/01～	Editorial board member, Journal of Neuroscience Research
2.	2022/10～	Grant reviewer Deutsche Forschungsgemeinschaft
3.	2022/08～	PLoS ONE Academic Editor
4.	2021/03～2021/12	Materials Special Issue "Self-Organization and Spontaneous Order for Functional Materials" Special Issue Editor
5.	2020/10～2021/08	Frontiers in Neuroscience "Development of Circadian Clock Functions" Topic Editor

■ Research Topics, Consignment Studies & KAKENHI Researches

1.	2020/10～2024/03	Mechanisms underlying aging and disease related circadian dysfunctions by in vivo Miniscope (Key Word : )
2.	2017/04～2023/03	Analysisi of oxidative stress-mediated postnatal neuronal development and behavior (Key Word : )
3.	2017/04～2020/03	Development of in vivo recording system for analyzing disturbance of these clock gene expression rhythms in freely moving mouse (Key Word : )
4.	2014/04～2017/03	Plasticity of the environmental adaptation in mice exposed to a "Social Jet-lag" condition (Key Word : )
5.	2011～2012	In vivo recording of brain temperatures from multiple site in mice. (Key Word : )
6.	2010/10～2011/03	Neural mechanisms of gonadal steroid hormone effectsin circadian rhythmicity (Key Word : )
7.	2009/04～2010/03	Vasoactive intestinal peptide (VIP) restores age-related sleep and circadian dysfunctions (Key Word : )
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■ Web Sites

Laboratory of Animal Physiology, School of Agriculture, Meiji University

http://www.meiji.ac.jp/agri/daigakuin/teacher/04/6t5h7p00000h9343.html

■ Award History

1.

2008/09

UCLA UCLA

■ Current Specialized Field

Key Word：Choronobiology,Chronopharmacology,Neuroendocrinology

■ KAKENHI Researcher Number

00581985

■ Courses and Lectures taught or delivered in the past

1.	Animal Physiology（Meiji University）
2.	Basic Baiology（Teikyo Heisei University）
3.	Anatomical Physiology（Teikyo Heisei University）
4.	Physiology
5.	Anatomical Physiology