Faculty Database - Asaga Hiroaki

Books and Papers

Conference Presentations

Academic Qualifications

researchmap Researcher Code

Research Topics, Consignment Studies & KAKENHI Researches

Current Specialized Field

KAKENHI Researcher Number

Courses and Lectures taught or delivered in the past

（Last updated : 2024-10-09 10:11:19）

Asaga Hiroaki
Department Undergraduate School , School of Commerce

Position Professor

■ Books and Papers

1.	2024/04	Article	Book Review of ”Kyouyouno　Seibutugaku” （second edition） (Single)
2.	2015/09	Article	A plant factory-like apparatus as an experimental teaching material for science education: assembly and experimental procedures Bull. Arts Sci. Meiji Univ. 509,pp.117-129 (Single)
3.	2013	Article	The Methodology of the Ethanol Patch Test as an Experimental Teaching Material in Life Science pp.77-92 (Single)
4.	2012/08	Article	Health promoting function of curry: A practical report of creating a new menu item reflecting concepts of cancer prevention and anti-aging Journal of Practical Education and Biology pp.8-15 (Collaboration)
5.	2012/03	Article	Effect of Radiation on the Human body: What is the Meaning of "The Level Has No Immediate Impact on Human Health"? Annals of Graduate School of Humanities Meiji University pp.71-97 (Single)
6.	2009/08	Article	Developmental and age-related changes of peptidylarginine deiminase 2 in the mouse brain J. Neurosci. Res. 87,pp.798-806 (Collaboration)
7.	2008/03	Article	Peptidylarginine deiminases and citrullination in the central nervous system. Bull. Arts Sci. Meiji Univ. 434,pp.7-33 (Single)
8.	2008/01	Article	Functional Evidence of Collagen (Gelatin) and Collagen Peptides by Oral Administration pp.5-11 (Single)
9.	2008/01	Article	Dynamic aspects of citrullinated proteins in human epidermis. Medicine and Biology 152(1),pp.26-33 (Collaboration)
10.	2007/06	Article	Microglial expression of peptidylarginine deiminase 2 in the prenatal rat brain. Cell Mol. Biol. Lett. 12(4),pp.536-544 (Collaboration)
11.	2005/08	Article	Amino acid ctrulline, wich is not encoded by gene, constitutes some proteins: Accumulation of citrullinated proteins in hippocampal extracts from Alzheimer's disease. J. Practical Educ. in Biol. pp.27-32 (Collaboration)
12.	2005/04	Article	Abnormal accumulation of citrullinated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer's disease. J. Neurosci. Res. 80,pp.120-128 (Collaboration)
13.	2002	Article	Protein deimination and peptidylarginine deiminase expression during cornification of rat epidermal keratinocytes. Biomed. Res. 23,pp.145-151. (Collaboration)
14.	2002	Article	Increaesed and type II-specific expression of peptidylarginine deiminase in activated microglia but not hyperplastic astrocytes following kainic acid-evoked neurodegeneration in the rat brain. Neurosci. Lett. 326,pp.129-132. (Collaboration)
15.	2002	Article	Human peptidylarginine deiminase type II: Molecular cloning, gene organization and expression in human skin. Arch. Biochem. Biophys. 407,pp.25-31. (Collaboration)
16.	2001	Article	Protein deimination in the rat brain after kainate administration: citrulline-containing proteins as a marker of neurodegeneration. Neurosci. Lett. 299,pp.5-8 (Collaboration)
17.	2001	Article	Peptidylarginine deiminase type I, type II, type III and type IV are expressed in rat epidermis. Biomed. Res. 22,pp.63-65. (Collaboration)
18.	2001	Article	Immunocytochemical localization of peptidylarginine deiminase type III, trichohyalin and deiminated trichohyalin in infant rat dorsal skin hair follicle. Biomed. Res. 22,pp.91-97 (Collaboration)
19.	2001	Article	Immunocytochemical localization of peptidylarginine deiminase in human eosinophils and neutrophils. J. Leukoc. Biol. 70,pp.46-51. (Collaboration)
20.	2001	Article	Morphogenesis- and hair cycle-dependent expression of trichohyalin, peptidylarginine deiminase type III and deiminated trichohyalin in rat dorsal skin hair follicles. Biomed. Res. 22,pp.265-271. (Collaboration)
21.	2000	Article	Protein deimination in the rat brain: generation of citrulline-containing proteins in cerebrum perfused with oxygen-deprived media. Biomed. Res. 21,pp.197-205 (Collaboration)
22.	2000/01	Article	Biological significance of citrullination of arginine residues in proteins catalized by peptidyl arginine deiminase.(in Japanese with English Abstract) Commun. Appl. Cell Biol pp.1-10. (Single)
23.	1999	Article	Molecular cloning of peptidylarginine deiminase in HL-60 cells induced by retinoic acid and 1α, 25-dehydroxyvitamin D3. J. Biol. Chem. 274,pp.27786-27792 (Collaboration)
24.	1998	Article	Deimination of 70-kD nuclear protein during epidermal apoptotic events in vitro. J. Histochem. Cytochem. 46,pp.1303-1309 (Collaboration)
25.	1998/01	Article	Ionomycin-induced cell death of mouse peritoneal macrophages: evaluation of the cell death by dye exclusion test and terminal deoxy-nucleotidyl transferase-mediated dUTP nick end labeling. Commun. Appl. Cell Biol. 15,pp.22-28 (Single)
26.	1998	Article	Selective deimination of vimentin in calcium ionophore-induced apoptosis of mouse peritoneal macrophages. Biochem. Biophys. Res. Commun. 243,pp.641-646 (Collaboration)
27.	1997	Article	Sexual maturation of albumen gland in land snail, Euhadra peliomphala. (in Japanese) Jpn. J. Appl. Entomol. Zool. pp.233-236 (Collaboration)
28.	1996	Article	Preferential deimination of keratin K1 and filaggrin during the terminal differentiation of human epidermis. Biochem. Biophys. Res. Commun. 225,pp.712-719 (Collaboration)
29.	1996	Article	Detection of several families of deiminated protreins derived from filaggrin and keratins in guinea pig skin. Zool. Sci. 13,pp.673-678 (Collaboration)
30.	1996	Article	Modifications of O'Farrell's two-dimensional electrophoresis of proteins for the reduction of artifactual bands and streaks. (in Japanese with English Summary) Commun. Appl. Cell Biol. pp.15-22 (Single)
31.	1995	Article	Detection of deiminated proteins in rat skin: probing with a monospecific antibody after modification of citrulline residues. J. Invest. Dermatol. 105,pp.163-169 (Collaboration)
32.	1994	Article	Effect of light condition and optic tentacle removal on the albumen gland in the land snail Euhadra peliomphala. (in Japanese with English Abstract) (Venus) Jpn. J. Malac. pp.211-216 (Collaboration)
33.	1994	Article	Studies on protein deimination in human epidermis and its possible alteration during aging. (in Japanese with English Abstract) Biomed. Gerontol. pp.302-303. (Collaboration)
34.	1993	Article	Combined biochemical and immunocytochemical analyses of postmortem protein deimination in the rat spinal cord. Cell Biol. Int. 17,pp.525-532 (Collaboration)
35.	1993	Article	Studies on possible causes of peptidylarginine deiminase activation in yound and aged rat cerebra by systemic perfusion. (in Japanese with English Abstract) Biomed. Gerontol. pp.148-149. (Collaboration)
36.	1992	Article	Detection of citrulline residues in deiminated proteins on polyvinylidene difluoride membrane. Anal. Biochem. 203,pp.94-100. (Collaboration)
37.	1992	Article	Recognition of collagen by fibroblasts through cell surface glycoproteins reactive with Phaseolus vulgaris agglutinin. J. Cell Sci. 101,pp.625-633. (Collaboration)
38.	1992	Article	Detection of amylase activity resolved by a simple polyacrylamide gel electrophoresis. (in Japanese) Chemical Education pp.700-701. (Collaboration)
39.	1992	Article	Age-dependent changes of peptidylarginine deiminase activity in rat cerebrum and immunocytochemical demonstration of it in various rat tissues. (in Japanese with English Abstract) Biomed. Gerontol. pp.148-149. (Collaboration)
40.	1992	Article	Hybrid artificial skin. (in Japanese) Tissue Culture pp.400-404. (Collaboration)
41.	1991	Article	Studies on the Mechanism of Recognition of Collagen by Fibroblasts Using a Reconstituted Dermal Model Tokyo Metropolitan University (Doctoral thesis) (Single)
42.	1991	Article	Collagen gel contraction by fibroblasts requires cellular fibronectin but not plasma fibronectin. Exp. Cell Res. 193,pp.167-174. (Collaboration)
43.	1991	Article	Bovine brain as a suitable teaching material for animal anatomy in senior high school biology. An example of lessons using it in biology classes. Jpn. J. Biol. Educ. pp.160-165. (Single)
44.	1990	Article	Two-dimensional gel electrophoretic analysis of the cerebella from neuro-pathologically mutant wever, nervous and staggerer mice. Develop. Growth Differ. 32,pp.223-232 (Collaboration)
45.	1990/06	Article	Cell biology of the reorganization of collagen gels. (in Japanese) Organic polymer gels, Kikan Kagaku Sosetsu, Japan Scientific Societies Press, Tokyo pp.153-160 (Collaboration)
46.	1990	Article	A simple polyacrylamide gel electrophoresis utilizing slides for biological education: Apparatus and experimental procedure. (in Japanese with English Abstract) Jpn. J. Biol. Educ. pp.107-115. (Collaboration)
47.	1990	Article	Fibroblasts to collagen interactions in the process of collagen gel contraction: Analysis of the mechanism of collagen gel contraction using monoclonal antibodies and lectins. Proceedings of the 37th Meeting of Japan Collagen Research Society pp.44-48. (Collaboration)
48.	1988	Article	Immunochemical confirmation of migration of albumen gland proteins to the egg of the land snail, Euhadra: Analysis of the proteins by two-dimensional gel electrophoresis and Western blotting method. Physico-Chem. Biol. 32,pp.135-140. (Collaboration)
49.	1987	Article	Comparative analysis of proteins from albumen glands and eggs of land snail, Euhadra, using Two-dimensional gel electrophoresis. Physico-Chem. Biol. pp.251-256. (Collaboration)
50.	1987	Article	Purification and biochemical characterization of egg-mass lectin of fresh water snail, Biomphalaria glabrata. Physico-Chem. Biol. pp.257-264 (Collaboration)
51.	1986	Article	Analysis of water-spluble protein composition of fresh water snails, Indoplanorbis exustus, I. corneas and Biomphalaria glabrata. Physico-Chem. Biol. pp.449-456. (Collaboration)
52.	1986	Article	Silver staining for proteins in SDS-polyacrylamide gel electrophoresis (in Japanese) Physico-Chem. Biol. pp.229-238. (Collaboration)
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■ Conference Presentations

1.	2003/11/13	Involvement of NDPK in signal transduction systems coupled to cell growth and differentiation. ("Fifth International Congress of the Genetics, Biochemistry and Physiology of NDP kinase/nm23/AWD,Lexington,KY,USA")
2.	2003/10	The role of NDPK in the NGF signaling cascade of PC12D cells. (第76回　日本生化学会大会)
3.	2003/06	Deiminated proteins in the brain of Alzheimer's disease. (The 26th Annual Meeting of the Japan Society for Biomedical Gerontology (Japan-Korea Gerontologists Joint Program))
4.	2002/10	Protein deimination (citrullination) in the model of neurodegeneration. (in English) (The 15th Naito Conference on Molecular Biological Approaches for Intractable Diseases [III])
5.	2001/11	Alterations of nm23/NDP kinase expression during differentiation of human myeloid leukemia HL-60 cells. . (Fourth International Congress of the Genetics, Biochemistry and Physiology of NDP kinase/nm23/AWD)
6.	1991/08	Direct interactions of fibroblast to collagen: Recognition of collagen by fibroblasts through cell surface glycoproteins reactive with Phaseolus vulgaris agglutinin. (3rd International Congress of Comparative Physiology and Biochemistry)
7.	1991/08	Indirect interactions of fibroblast to collagen via cellular fibronection: The binding site of native collagen fibril on a fibronectin molecule is different from that of denatured collagen. (International Symposium on Structure and Function of Extracellular Matrix)
8.	1990/03	Fibroblasts to collagen interactions in the process of collagen gel contraction: Analysis of the mechanism of collagen gel contraction using monoclonal antibodies and lectins. (English Speaking Session, The 37th Meeting of Japan Collagen Research Society)
9.	1989/08	Interactions of fibroblasts with collagen as revealed by monoclonal antibody techniques. (11th International Congress of the International Society of Developmental Biologists)
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■ Academic Qualifications

1.	1988/04～1991/03	〔Doctorial Course〕 Major in Biology (Developmental Physiology), Graduate School, Division of Natural Science, Graduate School of Tokyo Metropolitan University, Completed,
2.	1985/04～1987/03	〔Master Course〕 Major in Science Education (Biology), Graduate School, Division of Education, Graduate School of Tokyo Gakugei University, Completed,
3.	1981/04～1985/03	Science Department (Major in Biology), Faculty of Education, Tokyo Gakugei University, Graduated,

■ researchmap Researcher Code

0000024040

■ Research Topics, Consignment Studies & KAKENHI Researches

2003

Significance of protein citrullination in skin and central nervous system (Key Word : "proteins,citrullination,")

■ Current Specialized Field

Cell biology, Functional biochemistry, Science education, Science education

■ KAKENHI Researcher Number

80231877

■ Courses and Lectures taught or delivered in the past

1.	Life Science
2.	Biotechnology and Biobusiness
3.	New old biotechnology
4.	Biochemistry