Faculty Database - Nagashima Hiroshi

Books and Papers

Conference Presentations

Academic Qualifications

Web Sites

Award History

Current Specialized Field

Patents

（Last updated : 2024-10-29 11:18:45）

Nagashima Hiroshi
Department Undergraduate School , School of Agriculture

Position Professor

■ Books and Papers

1.	2024/08	Article	Generation of insulin-like growth factor 1 receptor-knockout pigs as a potential system for interspecies organogenesis Regenerative Therapy 26,pp.783-791 (Collaboration)
2.	2024/03	Article	The hybrid CL-SP-D molecule has the potential to regulate xenogeneic rejection by human neutrophils more efficiently than CD47 Transplant Immunology 84,pp.102020 (Collaboration)
3.	2024/01	Article	Material design of porous hydroxyapatite ceramics via inverse analysis of an estimation model for bone-forming ability based on machine learning and experimental validation of biological hard tissue responses Materials 17(3) (Collaboration)
4.	2024	Article	Pig models for translational Duchenne muscular dystrophy research Trends in Molecular Medicine 30(10),pp.950-964 (Collaboration)
5.	2023/11	Article	Effect of microgravity on mammalian embryo development evaluated at the international space station iScience 26(11) (Collaboration)
6.	2023/09	Article	Development of a panel for detection of pathogens in xenotransplantation donor pigs Xenotransplantation 12825 (Collaboration)
7.	2023/09	Article	Phenotypic features of dystrophin gene knockout pigs harboring a human artificial chromosome containing the entire dystrophin gene Molecular Therapy-Nucleic Acids 33,pp.444-453 (Collaboration)
8.	2023/09	Article	Phenotypic Features of Genetically Modified DMD-XKOXWT Pig Regenerative Therapy 24,pp.451-458 (Collaboration)
9.	2023/07	Article	Systemic deletion of DMD exon 51 rescues clinically severe Duchenne muscular dystrophy in a pig model lacking DMD exon 52 Proc Natl Acad Sci U S A 18(120) (Collaboration)
10.	2023	Book	Genome editing of pig Genome Editing in Animals: Methods and Protocols pp.269-292 (Collaboration)
11.	2022/12	Article	Development of a cryopreservation technique for xenogeneic kidney grafts: Evaluation using a mouse model Journal of Clinical Medicine 11(23),pp.7237 (Collaboration)
12.	2022/06	Article	Transplantation of human cells into Interleukin-2 receptor gamma gene knockout pigs under several conditions 12(21),pp.62-72 (Collaboration)
13.	2022/05	Article	Genetically engineered animal models for Marfan syndrome: challenges associated with the generation of pig models for diseases caused by haploinsufficiency Journal of Reproduction and Development 68(4),pp.233-237 (Collaboration)
14.	2022/04	Article	Aspects of the complement system in new era of xenotransplantation Frontiers in Immunology (Collaboration)
15.	2022/03	Article	Study of the CRISPR/Cas3 system for xenotransplantation Transplantation Proceedings 54(2),pp.522-524 (Collaboration)
16.	2022/03	Article	The innate cellular immune response in xenotransplantation Frontiers in Immunology (Collaboration)
17.	2021/12	Article	Generation of heterozygous PKD1 mutant pigs exhibiting early-onset renal cyst formation United States &Canadian Academy of Pathology 102(5),pp.560-569 (Collaboration)
18.	2021/11	Article	A scalable, clinically severe pig model for Duchenne muscular dystrophy Diseaese Models & Mechanisms (Collaboration)
19.	2021/07	Article	Characterization and treatment responsiveness of genetically engineered ornithine transcarbamylase-deficient pig Journal of Clinical Medicine 10(15),pp.3226 (Collaboration)
20.	2021/05	Article	Bioresorbable porous β-tricalcium phosphate chelate-setting cements with poly(lactic-co-glycolic acid) particles as pore-forming agent: fabrication, material properties, cytotoxicity, and in vivo evaluation Science and Technology of Advanced Materials 22(1),pp.511-521 (Collaboration)
21.	2021	Article	Feasibility of large experimental animal models in testing novel therapeutic strategies for diabetes World Journal of Diabetes 12(4),pp.306-330 (Collaboration)
22.	2020/11	Article	Genetically engineered pigs manifesting pancreatic agenesis with severe diabetes BMJ Open Diabetes Research and Care 8(e001792) (Collaboration)
23.	2020/10	Article	Investigation of clinical safety of human iPS cell-derived liver organoid transplantation to infantile patients in porcine model Cell Transplantation 29,pp.1-13 (Collaboration)
24.	2020/07	Article	Reactions to Porcine Cells With or Without β4GalNT2 Transplantion Proceedings 52(6),pp.1916-1918 (Collaboration)
25.	2020/06	Article	Development of an efficient vitrification mehod for chondrocyte sheets for clinical application Regenerative Therapy 14,pp.215-221 (Collaboration)
26.	2020/06	Article	Millimeter-thick xenoislet-laden fibers as retrievable transplants mitigate foreign body reactions for long-term glycemic control in diabetic mice Biomaterials 255,pp.120162 (Collaboration)
27.	2020/01	Article	Deficiency of circulating monocytes ameliorates the progression of myxomatous valve degeneration in marfan syndrome Circulation 141(2),pp.132-146 (Collaboration)
28.	2020	Article	DNA methylation ambiguity in the Fibrillin-1 (FBN1) CpG island shore possibly involved in Marfan syndrome Scientific Reports 10,pp.5287-5287 (Collaboration)
29.	2019/12	Article	Compensation of disabled organogeneses in genetically modified pig fetuses by blastocyst complementation Stem Cell Reports in press (Collaboration)
30.	2019/12	Article	Hollow fiber vitrification allows cryopreservation of embryos with compromised cryotolerance Reproductive Medicine and Biology 19,pp.142-150 (Collaboration)
31.	2019/12	Article	Natural flavonol, myricetin, enhances the function and survival of cryopreserved hepatocytes in vitro and in vivo International Journal of Molecular Sciences 20,pp.6123 (Collaboration)
32.	2019/10	Article	A strategy for suppressing macrophage-mediated rejection in xenotransplantation Transplantation 104(4),pp.675-681 (Collaboration)
33.	2019/05	Article	Anephrogenic phenotype induced by SALL1 gene knockout in pigs Scientific Reports 9(1),pp.8016-8016 (Collaboration)
34.	2019/05	Article	Distributions of endocrine cell clusters during porcine pancreatic development PLOS ONE (Collaboration)
35.	2019/04	Article	Silicon-containing apatite fiber scaffolds with enhanced mechanical property express osteoinductivity and high osteoconductivity Journal of Asian Ceramic Societies 7(2),pp.101-108 (Collaboration)
36.	2019	Article	The phenotype of a pig with monosomy X resembling Turner syndrome symptoms: a case report Journal of Reproduction and Development (Collaboration)
37.	2018/11	Article	Targeting aGal epitopes for multi-species embryo immunosurgery Reproduction, Fertility and Development (Collaboration)
38.	2018/10	Article	Preparation of anti-decay self-setting pastes of hydroxyapatite/collagen utilizing (3- glycidoxypropyl) trimethoxysilane Journal of Asian Creamic Societies (Collaboration)
39.	2018	Article	Effectiveness of bioengineered islet cell sheets for the treatment of diabetes mellitus Journal of Surgical Research 227,pp.119-128 (Collaboration)
40.	2018	Article	Fabrication of chelate-setting α-tricalcium phosphate cement using sodium citrate and sodium alginate as mixing solution and its in vivo osteoconductivity Journal of Biomedical Materials Research Part B: Applied Biomaterials 106(6),pp.2361-2370 (Collaboration)
41.	2018	Article	Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver Molecular Metabolism 11,pp.113-128 (Collaboration)
42.	2018	Article	Immunological response of pigs to human cells, including issues such as the production of natural antibodies in newborns Transplantation Proceedings 50(9),pp.2839-2841 (Collaboration)
43.	2018	Article	Production and rearing of germ-free X-SCID pigs Experimental Animals 67(2),pp.139-146 (Collaboration)
44.	2017/07	Book	Genome editing in pig Genome Editing of Animals: Methods and Protocols(Methods in Molecular Biology) 1630,pp.121-139 (Collaboration)
45.	2017/05	Article	Diabetic phenotype of transgenic pigs introduced by dominant-negative mutant hepatocyte nuclear factor 1α Journal of Diabetes and its Complications (Collaboration)
46.	2017/02	Article	Establishment of DNA methylation patterns of the Fibrillin1 (FBN1) gene in porcine embryos and tissues Journal of Reproduction and Development 63(1),pp.157-165 (Collaboration)
47.	2017	Article	Experimental hepatocyte transplantation in pigs Methods in Molecular Biology 1506,pp.149-160 (Collaboration)
48.	2017	Article	Studies of innate immune systems against human cells Transplant Immunology 40,pp.66-71 (Collaboration)
49.	2016/10	Article	A transgenic-cloned pig model expressing non-fluorescent modified plum Journal of Reproduction and Development 62(5),pp.511-520 (Collaboration)
50.	2016/07	Article	Growing human organs in pigs - A dream or reality? Theriogenology 86(1),pp.422-426 (Collaboration)
51.	2016/06	Article	An effective new cryopreservation procedure for pancreatic islets using hollow fiber vitrification Hormone and Metabolic Research 48(8),pp.540-549 (Collaboration)
52.	2016/06	Article	Temporal changes in cellular repopulation and collagen fibril remodeling and regeneration after allograft anterior cruciate ligament reconstruction The American Journal of Sports Medicine (Collaboration)
53.	2016/05	Article	Studies of pig complement: measurement of pig CH50, ACH50, and components Transplant Proc 48(4),pp.1282-1284 (Collaboration)
54.	2016/04	Article	Generation of heterozygous fibrillin-1 mutant cloned pigs from genome-edited foetal fibroblasts Scientific Reports 14(6),pp.24413 (Collaboration)
55.	2016/01	Article	Efficient modification of the myostatin gene in porcine somatic cells and generation of knockout piglets Molecular Reproducrion and Development 83(1),pp.61-70 (Collaboration)
56.	2016/01	Article	Ultra-deep bisulfite sequencing to detect specific DNA methylation patterns of minor cell types in heterogeneous cell populations: an example of the pituitary tissue PLOS ONE 11(1) (Collaboration)
57.	2016	Book	Organ Regeneration and transplantation using genetically modified pigs: Current state of research and relevant ethical issues Ethics for the future of iPS/stem cells (Single)
58.	2016	Article	Application of hollow fiber vitrification for cryopreservation of bovine early cleavage stage embryos and porcine morula-blastomeres Journal of Reproduction and Development in press (Collaboration)
59.	2016	Article	Measurement of pig CH50, ACH50, and components Transplantation Proceedings 48(4),pp.1282-1284 (Collaboration)
60.	2016	Article	Ubiquitous LEA29Y expression blocks T Cell co-stimulation but permits sexual reproduction in genetically modified pigs 11(5) (Collaboration)
61.	2015/07	Article	A new system to evaluate the influence of immunosuppressive drugs on pancreatic islets using epigenetics analysis in a 3-dimensional culture Pancreas 44(5),pp.778-785 (Collaboration)
62.	2015	Article	Generation of a felinized Swine endothelial cell line by expression of feline decay-accelerating factor Plos One (Collaboration)
63.	2015	Article	Nuclear transfer and transgenesis in the pig Nuclear Reprogramming 1222,pp.37-59 (Collaboration)
64.	2015	Article	Nuclear transfer and transgenesis in the pig Methods Mol Biol 1222,pp.37-59 (Collaboration)
65.	2015	Article	Urine excretion strategy for stem cell-generated embryonic kidneys National Academy of Science 112,pp.12980-12985 (Collaboration)
66.	2014/09	Article	Development of bioresorable calcium-phosphate cements hybridized with gelatin particles and their in vivo evaluation using pig's tibia model Key Eng Mater 631,pp.397-401 (Collaboration)
67.	2014	Article	A comparison of the main structures of N-glycans of porcine islets with those from humans Glycobiology 24,pp.25-38 (Collaboration)
68.	2014	Article	A conserved rule for pancreatic islet organization PLos One (Collaboration)
69.	2014	Article	A conserved rule for pancreatic islet rganization PLOS ONE 9(10) (Collaboration)
70.	2014	Article	Diffuse glomerular nodular lesions in diabetic pigs carrying a dominant- negative mutant hepatocyte nuclear factor 1-alpha, an inheritant diabetic gene in humans Plos One (Collaboration)
71.	2014	Article	Diffuse glomerular nodular lesions in diabetic pigs carrying a dominant- negative mutant hepatocyte nuclear factor 1-alpha, an inheritant diabetic gene in humans PLOS ONE 9,pp.9:e92219 (Collaboration)
72.	2014	Article	Production of transgenic cloned pigs expressing the far-red fluorescent protein monomeric Plum Journal of Reproduction and Development 61 (Collaboration)
73.	2014	Article	Results of life-supporting galactosyltransferase knockout kidneys in cynomolgus monkeys using two different sources of galactosyltransferase knockout Swin Transplantation 98,pp.419-426 (Collaboration)
74.	2014	Article	Transgenic pigs with pancres-specific expression of green fluorescent protein Journal of Reproduction and Development 60(3),pp.230-237 (Collaboration)
75.	2013/07	Article	A lectin microarray study of glycoantigens in neonatal porcine islet-like cell clusters Journal of Surgical Research 183(1),pp.412-418 (Collaboration)
76.	2013/05	Article	Permanent neonatal diabetes in INS(C94Y) transgenic pigs Diabetes 62(5),pp.1505-1511 (Collaboration)
77.	2013	Article	A Lectin array analysis for wild-type and a-Gal-knockout pig islets, compared with humans Surgery Today 43(12),pp.1439-1447 (Collaboration)
78.	2013	Article	Biodegradable β-Tricalcium Phosphate Cement with Anti- washout Property Based on Chelate-setting Mechanism of Inositol Phosphate Materials in Medicine (Collaboration)
79.	2013	Article	Biodegradable β-Tricalcium Phosphate Cement with Anti- washout Property Based on Chelate-setting Mechanism of Inositol Phosphate Materials in Medicine 24(6),pp.1383-1394 (Collaboration)
80.	2013	Article	Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs Proc Natl Acad Sci 110,pp.4557-4562 (Collaboration)
81.	2013	Article	Development of a novel vitrification method for chondrocyte sheets BMC Biotechnology 13,pp.58 (Collaboration)
82.	2013	Article	DNA methylation profiles provide a viable index for porcine pluripotent stem cells Genesis 51(11),pp.763-776 (Collaboration)
83.	2013	Article	Generating porcine chimeras using inner cell mass cells and parthenogenetic preimplantation embryos PLOS ONE (Collaboration)
84.	2013	Article	Generation of interleukin-2 receptor gamma gene knockout pigs from somatic cells genetically modified by zinc finger nuclease-encoding mRNA PLOS One (Collaboration)
85.	2013	Article	Generation of naïve porcine induced pluripotent stem cells capable of contributing to embryonic and fetal developmen Stem Cells and Development 22,pp.473-482 (Collaboration)
86.	2013	Article	Prodcution of diabetic offspring using cryopreserved epididymal sperm by in vitro fertilization and intrafallopian insemination techniques in transgenic pigs Journal of Reproduction and Development 59(6),pp.599-603 (Collaboration)
87.	2013	Article	Regulatory sequences of the porcine THBD gene facilitate endothelial-specific expression of bioactive human thrombomodulin in single- and multitransgenic pigs Transplantation (Collaboration)
88.	2013	Article	Transgenic pig expressing the res fluorescent protein kusabira-orange as a nobel tool for preclinical studies on hepatocyte transplantation Transplantation Proceedings 45,pp.1808-1810 (Collaboration)
89.	2012/11	Article	Completion of the swine genome will simplify the production of swine as a large animal biomedical model BMC Medical Genomics 55(5) (Collaboration)
90.	2012	Article	A cloning of cytidine monophospho-N-acetylneuraminic acid hydroxylase from porcine endothelial cells Transplantation Proceedings 44(4),pp.1136-1138 (Collaboration)
91.	2012	Article	A study of the glycoantigens of neonatal porcine islet-like cell clusters using a lectin microarray Transplantation Proceedings 44,pp.1134-1135 (Collaboration)
92.	2012	Article	Advancing pig cloning technologies towards application in regenerative medicine Reproduction in Domestic Animals 47(suppl4),pp.120-126 (Collaboration)
93.	2012	Article	Emerging applications of sperm, embryo and somatic cell cryopreservation in maintenance, relocation and rederivation of swine genetics theriogenology 78,pp.1720-1729 (Collaboration)
94.	2012	Article	Hollow Fiber Vitrification Provides a Novel Method for Cryopreserving In Vitro Maturation/Fertilization-Derived Porcine Embryos Biology of Reproduction (Collaboration)
95.	2012	Article	Hollow fiber vitrification: A novel method for vitrifying multiple embryos in a single device Journal of Reproduction and Development 588,pp.599-608 (Collaboration)
96.	2012	Article	Islets from rats and pigs transgenic for photogenic proteins Current Diabetes Review 8,pp.382-389 (Collaboration)
97.	2012	Article	Islets from rats and pigs transgenic for photogenic proteins Current Diabetes Reviews 8,pp.382-389 (Collaboration)
98.	2012	Article	Potential of primary kidney cells for somatic cell nuclear transfer mediated transgenesis in pig BMC Biotechnology 12,pp.84 (Collaboration)
99.	2012	Article	The creation of transgenic pigs expressing human proteins using BAC-derived, full-length genes and intracytoplasmic sperm injection-mediated gene transfer Transgenic Research 21(3),pp.605-618 (Collaboration)
100.	2012	Article	Xenografted islet cell clusters from INSLEA29Y transgenic pigs rescue diabetes and prevent immune rejection in humanized mice Diabetes 61,pp.1527-1532 (Collaboration)
101.	2012	Article	Xenotransplanted embryonic kidney provides a niche for endogenous mesenchymal stem cell differentiation into erythropoietin-producing tissue Stem Cells 30,pp.1228-1235 (Collaboration)
102.	2011/12	Book	The Minipig in Biomedical Research pp.Creation and conservation of genetically modified pigs: appl (Collaboration)
103.	2011/10	Article	The creation of transgenic pigs expressing human proteins using BAC-derived, full-length genes and intracytoplasmic sperm injection-mediated gene transfer Transgenic Research (Collaboration)
104.	2011/09	Article	Prevention of hyper-acute pulmonary xenograft dysfunction using GalT-KO swine in an ex-vivo lung perfusion model Xenotransplantation 18(5),pp.299 (Collaboration)
105.	2011	Book	Xenotransplantation pp.Human TRAIL expressing dendritic cells from transgenic pigs (Collaboration)
106.	2011	Article	Characterization of the ICSI-mediated gene transfer method in the production of transgenic pigs Molecular Reproduction and Development 79,pp.218-228 (Collaboration)
107.	2011	Article	Cloned porcine embryos can maintain developmental ability after cryopreservation at the morula stage Journal of Reproduction and Development 57,pp.312-316 (Collaboration)
108.	2011	Article	First inducible transgene expression in porcine large animal models The FASEB Journal 26,pp.1086-1099 (Collaboration)
109.	2011	Article	Human TNF-related apoptosis-inducing ligand-expressing dendritic cells from transgenic pigs attenuate human xenogeneic T cell responses Xenotransplantation 19,pp.40-51 (Collaboration)
110.	2011	Article	In vitro development and post-vitrification survival of cloned feline embryos derived from preadipocytes Journal of Reproduction and Development 57,pp.in press (Collaboration)
111.	2011	Article	Prevention of hyper-acute pulmonary xenograft dysfunction using GalT-KO swine in an ex-vivo lung perfusion model Xenotransplantation 18(4),pp.299 (Collaboration)
112.	2011	Article	Sequential targeting of CFTR by BAC vectors generates a novel pig model of cystic fibrosis Journal of Molecular Medicine (Collaboration)
113.	2010	Article	Comparison of transgene expression patterns in mouse embryos following ICSI-mediated gene transfer or pronuclear microinjection Bulletin of School of Agriculture Meiji University 60,pp.13-19 (Collaboration)
114.	2010	Article	Complement regulation in the GalT KO era Xenotransplantation 17,pp.11-25 (Collaboration)
115.	2010	Article	Developmental ability of porcine in vitro matured oocytes at the meiosis II stage after vitrification Journal of Reproduction and Development 56,pp.356-361 (Collaboration)
116.	2010	Article	Knockout of exogenous EGFP gene in porcine somatic cells using zink-finger nucleases Biochemical and Biophysical Research Communications 402,pp.14-18 (Collaboration)
117.	2010	Article	Necessity and possibility of serial cloning in development of advanced genetically engineered pigs for xenotransplantation Seoul Forum on Xenotransplantation pp.53-60 (Collaboration)
118.	2010	Article	Recent advances in production of genetically modified pigs for xenotransplantation Xenotransplantation 17,pp.94-120 (Collaboration)
119.	2010	Article	Survey of glycoantigens in cells from alpha1-3galactosyltransferase knockout pig using a lectin microarray Xenotransplantation 17,pp.61-70 (Collaboration)
120.	2009/04	Article	Production of cloned pigs by nuclear transfer of preadipocytes following cell cycle synchronization by differentiation induction Journal of Reproduction and Developmen 55,pp.121-127 (Collaboration)
121.	2009	Article	Application of genetically modified and cloned pigs in translational research Journal of Reproduction and Development 55,pp.225-230 (Collaboration)
122.	2009	Article	Dominant t-negative mutant hepatocyte nuclear factor 1alpha induces diabetes in transgenic-cloned pigs Transgenic Research (Collaboration)
123.	2009	Article	Two-year inhalation study of carcinogenicity and chronic toxicity of 1,4-dioxane in male rats Inhalation Toxicology 21,pp.889-897 (Collaboration)
124.	2008/09	Article	Transgenic-cloned pigs systemically expressing red fluorescent protein, kusabira-orange Cloning and Stem Cells 10,pp.313-324 (Collaboration)
125.	2008/08	Article	Production efficiency and telomere length of the cloned pigs following serial somatic cell nuclear transfer Journal of Reproduction and Development 54,pp.254-258 (Collaboration)
126.	2008/06	Article	Production of cloned pigs from salivary gland-derived progenitor cells Cloning and Stem Cells 10,pp.277-285 (Collaboration)
127.	2008/06	Article	Production of transgenic and non-transgenic clones in miniature pigs by somatic cell nuclear transfer Journal of Reproduction and Development 54,pp.156-163 (Collaboration)
128.	2008/02	Article	Effects of recloning on the efficiency of production of alpha 1,3-galactosyltransferase knockout pigs Journal of Reproduction Developement 54,pp.58-62 (Collaboration)
129.	2008/02	Article	Production of alpha 1,3-galactosyltransferase gene-deficient pigs by somatic cell nuclear transfer: a novel selection method for gal alpha 1,3-Gal antigen-deficient cells Molecular Reproduction and Development 75,pp.1372-1378 (Collaboration)
130.	2008	Article	Implication of multi-generational cloning in production of genetically modified pigs for xenotransplantation 4th Seoul Forum on Xenotransplantation pp.27-33 (Single)
131.	2007/12	Article	Effects of sperm pretreatment on efficiency of ICSI-mediated gene transfer in pigs Journal of Reproduction and Developmen 53,pp.1217-1226 (Collaboration)
132.	2007/04	Article	The production of a diabetic mouse using constructs encoding porcine insulin promoter-driven mutant human hepatocyte nuclear factor-1 alpha Journal of Reproduction and Development 53,pp.189-200 (Collaboration)
133.	2007/01	Article	Association between Embryonic loss and damage to the zona pellucida by invasive micromanipulation during oviductal transfer of early-stage embryos in pigs Journal of Reproduction and Development 53,pp.1113-1118 (Collaboration)
134.	2007/01	Article	Production of live piglets following cryopreservation of embryos derived from in vitro-matured oocytes Biology of Reproduction 76,pp.900-905 (Collaboration)
135.	2006/03	Article	Transplantation and differentiation of donor cells in the cloned pigs Biochemical and Biophysical Research Communications 344,pp.455-462 (Collaboration)
136.	2006	Article	Production of transgenic-clone pigs by the combination of ICSI-mediated gene transfer with somatic cell nuclear transfer. Transgenic Research 15,pp.229-240
137.	2005	Article	Differential development of rabbit embryos following midroinsemination with sperm and spermatids. Molecular Reproduction and Development 71,pp.in press (Collaboration)
138.	2005	Article	Effects of maturation conditions on spindle morphology in porcine M Ⅱ oocytes. Journal of Reproduction and Development 51,pp.405-410
139.	2005	Article	Evaluation of the quality porcine somatic cell nuclear transfer embryo by transcription profiles. Journal of Reproduction and Development 51,pp.123-131
140.	2005	Article	Preadipocytes as a novel nuclear donor cell for pig cloning. Journal of Reproduction Engineering 7,pp.303-307
141.	2005	Article	Production of 1,3-galactosyltransferase gene knockout pigs expressing both human decay accelerating factor and N-acetyglucosaminyltransferase Ⅲ. Molecular Reproduction and Development 71,pp.331-338 (Collaboration)
142.	2005	Article	Production of a transgenic pig expressing human albumin and enhanced green florescent protein. journal of Reproduction and Development 71,pp.in press (Collaboration)
143.	2005	Article	Production of cloned pigs by nuclear transfer of preadipocytes established from adult mature adipocytes. Cloning and Stem Cells 7,pp.279-288
144.	2004	Article	Cloning of the transgenic pigs expressing human decay acceleration factor and N-acetylglucosaminyltransferase Ⅲ. Cloning and Stem Cells 6,pp.294-301
145.	2004	Article	Cryopreservation of porcine embryos derived from in vitro-matured oocytes. Biology of Reproduction 71,pp.432-437
146.	2004	Article	Cytoplasmic asters are required for progression past the first cell cycle in cloned mouse embryos. Biology of Reproduction 71,pp.2022-2028 (Collaboration)
147.	2004	Article	Improved survival of vitrified in vivo-derived porcine embryos. Journal of Reproduction and Development 50,pp.481-486
148.	2004	Article	Sex differentiation and germ cell production in chimeric pigs produced by inner cell mass injection into blastocycts. Biological Reproduction 70,pp.702-707 (Collaboration)
149.	2003/11	Article	Sex differentiation and germ cell production in chimeric pigs produced by inner cell mass injection into blastocysts Biology of reproduction 70,pp.702-707 (Collaboration)
150.	2003	Article	Comparison of electro-fusion and intracytoplasmic nuclear injection methods in pig cloning Cloning and Stem Cells 5(4),pp.367-378 (Collaboration)
151.	2003	Article	Development of efficient strategies for the production of genetically modified pigs Theriogenology 59,pp.95-106 (Collaboration)
152.	2003	Article	Generation of transgenic rats expressing enhanced green fluorescent protein in gonadotropin-releasing hormone neurons. Journal of Reproduction Development 49,pp.523-529 (Collaboration)
153.	2003	Article	Microinsemination with first-wave round spermatids from immature male mice. Journal of Reproduction Development 50,pp.131-137 (Collaboration)
154.	2002	Article	Birth of offspring transplantation of cryopreserved immature testicular pieces and in-vitro microinsemination Human Reproduction 17,pp.3039-3045 (Collaboration)
155.	2002	Article	Bovine nucleus transplantation by intracytoplasmic injection Journal of Reproduction and Development 48,pp.619-626
156.	2002	Article	Calcium release at fertilization : Artificially mimicking the oocyte's response to sperm. Journal of Reproduction and Development 48,pp.313-333 (Collaboration)
157.	2002	Article	Developmental competence of in vitro matured porcine oocytes after electrical activation. Journal of Reproduction and Development 48,pp.271-279 (Collaboration)
158.	2002	Article	Developmental engineering for efficient production of transgenic pigs Transplantation Now 15,pp.256-260 (Collaboration)
159.	2002	Article	Improved postimplantation development of rabbit nuclear transfer embryos by activation with inositol 1,4,5-triphosphate Cloning and Stem Cell 4,pp.311-317 (Collaboration)
160.	2002	Article	In vitro development of porcine nuclear transfer embryos reconstructed by intracytoplasmic microinjection of cumulus cell nuclei into in vitro matured oocytes. Journal of Reproduction and Development 48,pp.121-129 (Collaboration)
161.	2001	Article	Remodeling of the major pig xenoantigen by N-acetylglucosaminyltransferase III in transgenic pig J Biol Chem 276,pp.39310-39319 (Collaboration)
162.	2000/09	Article	Production of transgenic pigs expressing human DAF(CD55) regulated by the porcine MCP gene promotor Transplantaion Proceedings 32,pp.2505-2506 (Collaboration)
163.	1999/04	Article	Production of transgenic pig carrying MMTV/v-Ha-ras Japanese Society of Animal ReproductionJournal of Reproduction & Development 45(2),pp.111-118 (Collaboration)
164.	1999/04	Article	Survival of porcine delipated oocytes and embryos after cryopreservation by freezing or vitrification Japanese Society of Animal ReproductionJournal of Reproduction & Development 45(2),pp.167-176 (Collaboration)
165.	1999	Article	Cryopreservation of bovine pre-morula-stage in vitro matured/in vitro fertilized embryos after delipidation and before use in nucleus transfer Biology of Reproduction 60,pp.534-539 (Collaboration)
166.	1998	Article	Improved viability of boar semen frozen after Percoll density gradient centrifugation Journal of Reproduction Engineering 1,pp.12-18 (Collaboration)
167.	1998	Article	Removal of cytoplasmic lipid droplets from porcine and bovine ova Journal of Reproduction and Development 1,pp.19-24 (Collaboration)
168.	1997	Article	Asynchronous meiotic progression in porcine oocytes matured in vitro: a cause of polyspermic fertilization Reproduction, Fertility and Development 9,pp.187-191 (Collaboration)
169.	1997	Article	Nuclear transfer of porcine embryos using cryopreserved deplipated blastomeres as donor nuclei Molecular Reproduction and Development 48,pp.339-343 (Collaboration)
170.	1997	Article	Production and analysis of growth hormone transgenic pigs Transgenic Animal in Agriculture (Collaboration)
171.	1997	Article	Role of epidermal growth factor and insulin-like growth factor-l on porcine oocyte maturation and embryonic development in vitro Reproduction, Fertility and Development 9,pp.571-576 (Collaboration)
172.	1996	Article	Developmental competence of in vivo and in vitro matured porcine oocytes after subzonal sperm injection Molecular Reproduction and Development 45,pp.359-363 (Collaboration)
173.	1996	Article	Freezing of in vivo derived and in vitro pre-cultured porcine blastocysts : Differences of the cryoprotective effect between glycerol and ethylene glyco Journal of Reproduction and Development 42,pp.193-197 (Collaboration)
174.	1995	Article	Cryopreservation of porcine embryos Nature 374,pp.416 (Collaboration)
175.	1995	Article	Cysteamine enhances in vitro development of in vitro matured and fertilized porcine oocytes Biology of Reproduction 53,pp.173-178 (Collaboration)
176.	1995	Article	Improved survival of porcine hatched blastocysts cryopreserved with glycerol and sucrose Journal of Reproduction and Development 41,pp.165-170 (Collaboration)
177.	1995	Article	In vitro and in vivo development of cloned ovine embryos using in vitro and in vivo matured oocytes Reproduction in Domestic Animals 30,pp.125-128 (Collaboration)
178.	1994	Article	Removal of cytoplasmic lipid enhances the tolerance of porcine embryos to chilling Biology of Reproduction 51,pp.618-622 (Collaboration)
179.	1993	Article	In vitro development of in vitro and in vivo fertilized porcine zygotes Journal of Reproduction and Development 39,pp.163-168 (Collaboration)
180.	1993	Article	Tumorigenesis and gene transmission in transgenic mice carrying MMTV/v-Ha-ras Journal of Reproduction and Development 39,pp.259-268 (Collaboration)
181.	1992	Article	Ability of porcine blastomere nuclei derived from 8- to 16-cell stage embryos to support development following transfer to enucleated oocytes in vitro Assis Reprod Tech/Andro 259,pp.257-266 (Collaboration)
182.	1992	Article	Freezability of porcine blastocysts at different peri-hatching stages Theriogenology 37,pp.839-850 (Collaboration)
183.	1992	Article	Transplantation of porcine blastomere nuclei into oocytes collected from prepubertal gilts Journal of Reproduction and Development 38,pp.79-78 (Collaboration)
184.	1991	Article	Cryopreservation of mouse half-morulae and chimeric embryos by vitrification Molecular Reproduction and Development 30,pp.220-225 (Collaboration)
185.	1990	Article	The survival of whole and bisected rabbit morulae after cryopreservation by vitrification method Theriogenology 33,pp.777-788 (Collaboration)
186.	1989	Article	Changes in freezing tolerance of pig blastocysts in peri-hatching stage The Japanese Journal of Animal Reproduction 35,pp.130-134 (Collaboration)
187.	1989	Article	Changes in plasma gonadotropins, ovarian steroids and inhibin concentrations in gilts following progesterone treatment with implantable osmotic pumps Animal Reproduction Science 20,pp.287-297 (Collaboration)
188.	1989	Article	Microsurgical bisection of porcine morulae and blastocysts to produce monozygotic twin pregnancy Gamete Research 23,pp.1-9 (Collaboration)
189.	1989	Article	Normal development of follicular oocytes collected from prepubertal gilts after gamete intrafallopian transfer The Japanese Journal of Animal Reproduction 35,pp.217-221 (Collaboration)
190.	1988	Article	Are fluorescent bodies of Y-spermatozoa detectable in common with mammalian species? Theriogenology 29,pp.1083-1089 (Collaboration)
191.	1988	Article	Production of normal piglets from microsurgically split morulae and blastocyst Theriogenology 29,pp.485-495 (Collaboration)
192.	1988	Article	Sexing of half-embryos produced by microsurgical bisection of mouse morulae and production of chimeric mouse of defined sex composition by aggregating two sexed half-embryos Experimental Animals 37,pp.127-135 (Collaboration)
193.	1988	Article	Survival of pig hatched blastocysts exposed below 15 ℃ The Japanese Journal of Animal Reproduction 34,pp.123-131 (Collaboration)
194.	1987	Article	Microsurgical bisection of expanding blastocysts for sexing of pig embryos he Japanese Journal of Animal Reproduction 33,pp.151-154 (Collaboration)
195.	1987	Article	Nonsurgical collection of embryos in Shiba goats Experimental Animals 36,pp.1-56 (Collaboration)
196.	1984	Article	Production of monozygotic mouse twins from microsurgically bisected morulae Journal of Reproduction and Fertility 70,pp.327-362 (Collaboration)
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■ Conference Presentations

1.	2023/06/02	Current status and challenges of the development of genetically engineered pigs in Japan (第60回日本小児外科学会学術集会)
2.	2019/10/10	Production of medical grade pigs using the uterectomy-isolated rearing (U-iR) method (15th Congress of the International Xenotransplantation Association)
3.	2019/02/21	The strategies for preventing the macrophage-mediated rejection in xenotransplantation (Asia Pancreas and islet Transplantation Association (APITA2019))
4.	2018/09/20	Comparative analysis of mouse and pig models of Marfan syndrome unveils an inflammatory micro-environment and macrophages as novel features of myxomatous valve disease (Molecular and Developmental Biology Symposium)
5.	2018/09/17	Comparative analysis of mouse and pig models of Marfan syndrome unveils an inflammatory micro-environment and macrophages as novel features of myxomatous valve disease (Heart Institute Retreat:)
6.	2018/09/15	Phenotypic features of an X-monosomy pig
7.	2018/09/14	Analysis of semen property in the diabetes model transgenic pig
8.	2018/09/14	Control of the pathogenic mechanism of Marfan syndrome model pigs
9.	2018/09/14	Preservation of a pig ejaculated sperm using the GP Long
10.	2018/09/14	Production of Duchenne muscular dystrophy model pig
11.	2018/09/06	Comparative analysis of mouse and pig models of Marfan syndrome unveils an inflammatory micro-environment and macrophages as novel features of myxomatous valve disease (Mid-America Valve Conference)
12.	2018/09/06	Cryopreservation of bioengineered cell sheet by vitrification (5th Tissue Engineering and Regenerative Medicine International Society World Congress)
13.	2018/07/13	Immunogenic extracellular matrix remodeling and macrophage contributions to heart valve disease in genetic mouse and pig models of Marfan syndrome (33rd National MD/PhD Student Conference)
14.	2018/05/03	A novel large animal disease model of marfan syndrome: FBN1 edited pigs (10th International Research Symposium on Marfan Syndrome and Related Disorders)
15.	2018/05/03	DNA methylation as an epigenetic modifier of the FBN1 transcription (10th International Research Symposium on Marfan Syndrome and Related Disorders)
16.	2018/05/03	Phenotype of homozygous fibrillin-1(FBN1) mutant pigs (10th International Research Symposium on Marfan Syndrome and Related Disorders)
17.	2017/11/09	Development of genetically engineered pig models for rare monogenic diseases (Association for Laboratory Animal Science Conference 2017)
18.	2017/11	The immunological response of pigs anti-human cell, included issues such as the production of natural antibodies in newborn (15th Congress of Asian Society of Transplantation (CAST2017))
19.	2017/10/30	Osteoinduction of porous calcium-phosphate ceramics in pig femoral muscle (17th Asian BioCeramics Symposium)
20.	2017/10/25	Material properties of chelate-setting cements with various cross-linked gelatin particles as pore-forming agents and their biological evaluations (Bioceramics 29)
21.	2017/09/27	Development of vitrified blastomeres of genotyped porcine embryos (Fourth World Congress of Reproductive Biology (WCRB2017))
22.	2017/09/27	Faithful genetic inheritance of autosomal dominant polycystic kidney disease generated by genome editing of the cloned pig (Fourth World Congress of Reproductive Biology (WCRB2017))
23.	2017/09/27	Generation of genome edited pigs by cytoplasmic injection of TALEN or CRISPR/cas9 mRNA into zygotes (Fourth World Congress of Reproductive Biology (WCRB2017))
24.	2017/09/27	Generation of SALL1 knockout pigs using the CRISPR/Cas9 system via cytoplasmic injection (Fourth World Congress of Reproductive Biology (WCRB2017))
25.	2017/09/27	Generation of SALL1 KO pigs by cytoplasmic injection of Platinum TALEN mRNA into zygotes (Fourth World Congress of Reproductive Biology (WCRB2017))
26.	2017/09/27	nduced chimerism rescues lethal trait of Duchenne muscular dystrophy (DMD) model pig (Fourth World Congress of Reproductive Biology (WCRB2017))
27.	2017/09/27	Phenotypic variation in the cloned pigs with heterozygous fibrillin-1 mutation (Fourth World Congress of Reproductive Biology (WCRB2017))
28.	2017/09/27	Post-mortem sperm regeneration from genetically modified disease model pigs (Fourth World Congress of Reproductive Biology (WCRB2017))
29.	2017/09	The innate immunological response of pigs against humans (14th Congress of the International Xenotransplantation Association (IXA2017))
30.	2017/06/05	Genetically modified diabetes model pigs characterized by complications (Kyoto DIabetes Mini-Symposium)
31.	2017/03/19	Development of a vitrification method for polydactyly-derived chondrocyte sheets for regeneration of articular cartilage (Orthopaedic Research Society 2017)
32.	2016/11/09	ROSA26-targeted knock-in using CRISPR/Cas9 system in pigs (The 29th Annual and International Meeting of the Japanese Association for Animal Cell Technology)
33.	2016/09/12	Generation of human organs in pigs (4th German Stem Cell Network Conference)
34.	2016/09/03	Development of cryopreservation method for polydactyly derived chondrocyte sheets by vitrification (Tissue Engineering and Regenerative Medicine International Society- Asia Pacific Meeting (TERMIS-AP))
35.	2016/06/28	Pig models of rare monogenic diseases (18th International Congress of Animal Reproduction, SALAAM-Workshop)
36.	2016/06/07	Combining breeding and advanced reproduction techniques for regenerative medicine (Plan and Animal Genome Asia 2016)
37.	2016/06	Genetically modified pigs with ornithine transcarbamylase deficiency produced by genome editing and somatic cell cloning (18th International Congress of Animal Reproduction)
38.	2016/06	Genotyping and cryopreservation of in vitro produced porcine embryos (18th International Congress of Animal Reproduction)
39.	2016/06	Growing human organs in pigs - a dream or reality? (18th International Congress of Animal Reproduction)
40.	2016/03/10	Cryopreservation of cloned porcine embryos by hollow fiber vitrification (International Symposium on the Future of Nuclear Transfer and Nuclear Reprogramming)
41.	2016/03/10	Generation of genome edited pigs by nuclear transfer (International Symposium on the Future of Nuclear Transfer and Nuclear Reprogramming)
42.	2016/03/10	Production of the multigenerational cloned pigs by serial nuclear transfer (International Symposium on the Future of Nuclear Transfer and Nuclear Reprogramming)
43.	2015/12/15	Fabrication of vascular endothelial growth factor-loaded apatite-fiber scaffolds with enhanced mechanical property and their biological evaluation (Pacifichem 2015)
44.	2015/12/03	Generation of genetically modified pigs by genome editing (Biochemistry and Molecular Biology 2015)
45.	2015/11	Production of alpha 1,3-galactosyltransferase and cytidine monophosphate-N-acetylneuraminic acid hydroxylase gene double-knockout pigs by genome editing and somatic cell cloning (2015 IPITA-IXA-CTS Joint Congress:)
46.	2015/10/27	In Vivo Evaluation of Bioresorbable b-tricalcium phosphate Cements with Pore-forming Agents Using a Pig Tibia Mode (27th Symposium and Annual Meeting of the International Society for Ceramics in Medicine)
47.	2015/10	Fabrication of silicon-containing apatite fiber scaffolds with enhanced mechanical property and their bone-forming ability in hard and soft tissues (27th Symposium and Annual Meeting of the International Society for Ceramics in Medicine)
48.	2015/08/23	Studies of pig complement: measurement of pig CH50, ACH50, and components (14th Congress of the Asian Society of Transplantation)
49.	2015/05/15	(Production of heterozygous fibrillin-1 gene knockout cloned pigs using zinc finger nuclease.)
50.	2015/04/28	Direct comparison of the hollow-fiber vitrification ad conventional vitrification methods (International Federation of Fertility Societies)
51.	2015/01/15	Challenge to in-vivo organ regeneration using organogenesis-disabled pig as a platform (REBIRTH-Special Lecture)
52.	2015/01/10	Application of the hollow fiber vitrification method to the cryopreservation of highly cryosensitive embryos (41th Annual Conference of the International Embryo Transfer Society)
53.	2014/11/06	Development of bioresorbable calcium-phosphate cements hybridized with gelatin particles and their in vivo evaluation using pig's tibia mode (26th Symposium and Annual Meeting of the International Society for Ceramics)
54.	2014/10/10	Aiming at allogeneic transplantation the effect on articular cartilage repair using vitrificated chondrocyte sheets
55.	2014/10/09	Dystrophin-deficient pigs provide new insights into the hierarchy of physiological derangements of dystrophic muscle (19th International Congress of The World Muscle Society)
56.	2014/09	Hollow fiber vitrification of in vitro produced bovine embryos at early developmental stages (World Congress of Reproductive Biology 2014)
57.	2014/09	Transmission of lethal phenotype in a Mendelian fashion by genetically modified pigs that underwent blastocyst complementation (World Congress of Reproductive Biology 2014)
58.	2014/08/29	Organ regeneration and transplantation research using genetically modified pigs: current status and issues (2014 Uehiro-Carnegie-Oxford Ethics Conference)
59.	2014/07	Cryopreservation of porcine zona-free embryos and isolated blastomeres using the hollow fiber vitrification method (Swine in Biomedical Research International Conference 2014)
60.	2014/07	Development of apancreatic pig by genome editing and its application in organ regeneration research (Swine in Biomedical Research International Conference 2014)
61.	2014/07	Generation of X-linked SCID pigs by genome editing and somatic cell cloning (Swine in Biomedical Research International Conference 2014)
62.	2014/07	Production of fibrillin-1 gene knockout cloned pigs using zinc finger nuclease (Swine in Biomedical Research International Conference 2014)
63.	2014/06	Challenge to organ regeneration by usign organogenesis-disabled pig as the platform (Swine in Biomedical Research Conference2014)
64.	2014/05/14	Diffuse glomerular nodular lesions in diabetic pigs carrying a dominant-negative mutant hepatocyte nuclear factor one-alpha, an inheritant diabetic gene in humans (The 14th Asian Pacific Congress of Nephrology 2014)
65.	2014/05/04	Diabetic retinopathy in transgenic pigs with induced diabetes mellitus (The Association for Research in Vision and Ophthalmology 2014 Annual Meeting)
66.	2014/01/11	Generation and characterization of transgenic-cloned pigs expressing the far-red fluorescent protein monomeric plum (40th Annual Conference of the International Embryo Transfer Society)
67.	2014/01/11	In vivo exogenic organ generation with organogenesis-disabled cloned pigs as a platform (40th Annual Conference of the International Embryo Transfer Society)
68.	2014/01/11	Practical application of the hollow fiber vitrification method for cryopreservation of mammalian embryos (40th Annual Conference of the International Embryo Transfer Society)
69.	2013/12/05	Evaluation of porcine induced pluripotent stem cells based on the DNA methylation profile of mouse embryonic stem cell-specific hypomethylated loci (第36回日本分子生物学会)
70.	2013/12/04	In vitro and in vivo evaluations of apatite-fiber scaffolds loaded with vascular endothelial growth facto (13th Asian BioCeramics Symposium)
71.	2013/11/13	Application of blastocyst complementation to development of genetically modified pigs for xenotransplantation (12th Congress of International Xenotransplantation Association)
72.	2013/11/13	In vivo generation of exogenic pancreas in apancreatic cloned pigs via blastocyst complementation (2th Congress of International Xenotransplantation Association)
73.	2013/11/13	Tg pigs- recent progress: Multiple Tg+GalTKO (Joint IXA/JEXSPINE Plenary Session)
74.	2013/11/10	The adult porcine islets preparation contained several glycans that were not detected in human islets (The 12th International Xenotransplantation Association)
75.	2013/11/10	The structure of N-glyacns of neonatal porcine islet-like cell clusters (The 12th International Xenotransplantation Association)
76.	2013/11/07	Evolution of glomerular nodular lesions in diabetic pigs carrying a dominant-negative mutant hepatocyte nuclear factor 1-alpha (KIDNEY WEEK 2013(American Society of Nephrology))
77.	2013/10/27	Development of chelate-setting cement with enhanced bioactivity using silicon-containing hydroxyapatite powder (International Symposium on Inorganic and Environmental Material 2013:)
78.	2013/10/13	Genetically engineered and systemically expressing kusabira-orange transgenic pigs as in vivo model to trace cell recruitment after anterior cruciate ligament reconstruction (8th Combined Meeting of Orthopaedic Research Society)
79.	2013/07/05	Fabrication of α-tricalcium phosphate cement using chelating mechanism of inositol phosphate and Its histological evaluation (6th International Symposium on Apatite and Correlative Biomaterials)
80.	2013/06/01	Pathological analysis of glomerular nodular lesion in diabetic pigs carrying a dominant-negative mutant hepatocyte nuclear factor 1-alpha (The International Society of Nephrology World Congress of Nephrology 2013)
81.	2013/03/15	The analyses of collagen fascicle remodeling along with cell recruitment after anterior cruciate ligament reconstruction in Kusabira-Orange transgenic pigs (60th Annual Meeting of the Orthopaedic Research Society)
82.	2013/01/19	A hollow fiber vitrification method enables cryobanking of IVM/IVF-derived transgenic pig embryos (39th Annual Conference of the IETS)
83.	2013/01/19	Generation of a double-transgenic pig with pancreas-specific green and iver-specific red fluorescence (39th Annual Conference of the International Embryos Transfer Society)
84.	2013/01/19	Production of chimeric porcine fetuses by aggregation method using parthenogenetic embryos (39th Annual Conference of the IETS)
85.	2013/01/19	Production of genetically modified pigs by artificial reproductive technologies using frozen epididymal sperm (39th Annual Conference of the IETS)
86.	2013	Evolution of glomerular nodular lesions in diabetic pigs carrying a dominant-negative mutant hepatocyte nuclear factor 1-alpha (Kidney Week)
87.	2012/12/13	Production and application of transgenic-cloned pigs expressing far-red fluorescent protein, monomeric Plum (The 35th Annual Meeting of the MBSJ)
88.	2012/07/29	Advancing pig cloning technologies towards application in regenerative medicine (17th International Congress on Animal Reproduction)
89.	2012/07/29	Hollow fiber vitrification(HFV) method enables cryopreservation of cryosensitive porcine embryos (17th International Congress on Animal Reproduction)
90.	2012/07/29	Transmission and expression of a retrovirally introduced red fluorescent protein gene in successive generations of transgenic pigs (17th International Congress on Animal Reproduction)
91.	2012/07/15	Adult Pig Islets, Rich in the High-Mannose Form Compared with Humans, Were Slightly Up-Regulated, and Alpha-Linked GalNAc Was Reduced by Gal-Knockout (24th International Congress of the Transplantation Society)
92.	2012/07/15	Attenuation of Hyperacute Dysfunction and Coagulopathy in GalT-KO Pulmonary Xenotransplantation (24th International Congress of the Transplantation Society)
93.	2012/07/15	Beta-Cell Specific Expression of LEA29Y Prevents Cellular Rejection in Islet Xenotransplantation (24th International Congress of the Transplantation Society)
94.	2012/07/15	Expression of Human Thrombomodulin on the Endothelium of Pig Xenograft Donors (24th International Congress of the Transplantation Society)
95.	2012/07/15	Phenotypic Characterization of Diabetic INSC94Y Transgenic Pigs (24th International Congress of the Transplantation Soceity)
96.	2012/07/15	Transgenic Pig Expressing Red Fluorescent Protein, Kusabila-Orange as a Novel Tool for Preclinical Research of Hepatocyte Transplantation (24th International Congress of the Transplantation Society)
97.	2012/06/13	Development of a feasible verification system for pluripotent stem cells using porcine Parthenogenetic embryos (International Society for Stem Cell Research 10th Annual Meeting)
98.	2012/06/13	Generation of naïve porcine induced pluripotent stem cells capable of contributing to embryonic and fetal development (International Society for Stem Cell Research 10th Annual Meeting)
99.	2012/06/13	Transgenic pigs with pancreas and liver specific expression of fluorescent proteins (International Society for Stem Cell Research 10th Annual Meeting)
100.	2012/02/07	Genetically engineered and systemically expressing kusabira-orange transgenic pigs as in vivo model to trace cell recruitment after anterior cruciate ligament reconstruction (Orthopaedic Research Society2012)
101.	2011/10/23	126-GalT-KO/CD46/hTM triple-transgenic donor animals for pig-to-baboon heart transplantation (Joint Congress CTS-IXA2011)
102.	2011/10/12	Establishment of In Vitro Fertilization Protocol Using Cryopreserved Epididymal Sperm for Proliferation of Genetically Modified Pigs (World Congress on Reproductive Biology (Second Scientific Meeting))
103.	2011/10/12	High performance cryopreservation of porcine embryos by the hollow fiber vitrification(HFV)-method (World Congress on Reproductive Biology (Second Scientific Meeting))
104.	2011/10/12	Hollow fiber vitrification (HFV) method: a novel high performance embryo cryopreservation method (World Congress on Reproductive Biology (Second Scientific Meeting))
105.	2011/10/12	In vitro-maturation/fertilization derived porcine morulae can give rise to efficient piglet production following vitrification by the hollow fiber vitrification(HFV)-method (World Congress on Reproductive Biology (Second Scientific Meeting))
106.	2011/10/12	The interface between reproductive biology and regenerative medicine (World Congress on Reproductive Biology (Second Scientific Meeting))
107.	2011/10/09	Hollow fiber vitrification (HFV) method: a novel high performance embryo cryopreservation method (World Congress on Reproductive Biology (Second Scientific Meeting))
108.	2011/09/13	hHG is critical for the uterine decidual response in mice (16th World Congress on In Vitro Fertilization)
109.	2011/09/10	hHg is critical for the uterine decidual response in mice (16th World Congress on In Vitro Fertilization)
110.	2011/07/29	Hollow fiber vitrification(HFV) method enables cryopreservation of cryosensitive porcine embryos (17th International Congress on Animal Reproduction)
111.	2011/07/29	Transmission and expression of a retrovirally introduced red fluorescent protein gene in successive generations of transgenic pigs (17th International Congress on Animal Reproduction)
112.	2011/07/17	A challenge to developing humanized kidney using porcine renal anlagen as scaffold (Swine in Biomedical Research Conference 2011)
113.	2011/07/17	A Challenge to Developing Humanized Kidney using Porcine Renal Anlagen as Scaffold (Swine in Biomedical Research Conference 2011)
114.	2011/07/17	Determination of transgene integration loci by inverse PCR for multi-transgenic pig breeding (Swine in Biomedical Research 2011)
115.	2011/07/17	Development of genetically modified pigs suitable for diabetes and its complications research (Swine in Biomedical Research Conference 2011)
116.	2011/07/17	Efficient targeting of genomic loci in the pig and production of knockout pigs by somatic cell nuclear transfer (Swine in Biomedical Research 2011)
117.	2011/07/17	Establishment of LEA29Y transgenic donor pigs for xenotransplantation (Swine in Biomedical Research 2011)
118.	2011/07/17	Phenotypic characterization of diabetic INSC94Y transgenic pigs (Swine in Biomedical Research 2011)
119.	2011/07/17	Tet-controlled transgene expression in large animal models (Swine in Biomedical Research 2011)
120.	2011/07/17	Transgenic pigs expressing the mutant insulin C93S for the study of pancreatic beta cell dysfunction (Swine in Biomedical Research 2011)
121.	2011/01	Large-scale production of cloned transgenic pigs: efficiency and side effects (2011 Annual Conference of the International Embryo Transfer Society)
122.	2011/01	The generation of “mouse-type” porcine induced pluripotent stem cells ("Keystone Symposia: Stem Cells in Development, Tissue Homeostasis and Disease (B3)")
123.	2010/12	"Cell proliferation, morphology and differentiation of transgenic-cloned pig calvarial osteoblasts on the silicon-substituted hydroxyapatite ceramics fabricated via ultrasonic spray-pyrolysis technique" (5th International Symposium on Apatites and Correlative Biomaterials)
124.	2010/12	Characterization of transgene-free porcine iPS cell (第33回日本分子生物学会年会)
125.	2010/12	Zinc-finger nucleases(ZFNs) -driven gene disruption can work in porcine primary cultured cells (第33回日本分子生物学会年会)
126.	2010/11	Necessity and possibility of serial cloning in development of advanced genetically engineered pigs for xenotransplantation (2010 Seoul Forum on Xenotransplantation)
127.	2010/10	A novel vitrification method using a microfiltration membrane(MFM) enables a simple manipulation of human embryos (American Society for Reproductive Medicine 66th Annual Meeting)
128.	2010/06	Increased longevity of old mice after allo-transplantation of young mice ovaries (26th Annual Meeting of European Society of Human Reproduction and Embryology)
129.	2010/03/28	Production of the sixth generation cloned pigs by serial somatic cell nuclear transfer
130.	2009/10	Function of vitrified human ovarian grafts after xeno-transplantation (65th Annual Meeting of the American Society for Reproductive Medicine)
131.	2009/06	Recent advances in production of genetically modified pigs for xenotransplantation (International Symposium Xenotransplantation)
132.	2009/06	Recovery of reproductive function and extension of life expectancy in old infertile mice by ovarian transplantation (25th Annual Meeting of the Europian Society of Human Reproduction and Embryology)
133.	2008/08	"Reproduction of homozygous α1,3-galactosyltransferase gene knock-out pigs by somatic cell cloning" (XXII International Congress of The Transplantation Society)
134.	2008/04	Feasibility of serial somatic cell nuclear transfer in pigs ("Swine in Biomedical Research Conference, San Diego")
135.	2008/01	In vitro culture and cryopreservation of feline cloned embryos reconstructed with preadipocytes (34th Annual Conference of the International Embryo Transfer Society)
136.	2008/01	Transgenic cloned pigs expressing orange fluorescent protein Kusabira-Orange (34th Annual Conference of the International Embryo Transfer Society)
137.	2008/01	Vitrification of in vitro matured porcine oocytes at the MII stage (34th Annual Conference of the International Embryo Transfer Society)
138.	2008	Implication of multi-generational cloning in production of genetically modified pigs for xenotransplantation (4th Seoul Forum on Xenotransplantation)
139.	2007/08	Transgenic cloned pigs expressing orange fluorescent protein (short presentation) (KEIO International Symposium on Photonics and Molecular Therapy)
140.	2007/03	"Expression of orange fluorescent protein ""Kusabira-Orange""in the transgenic-cloned pig" (明治大学ハイテクリサーチセンター公開シンポジウム)
141.	2007/03	Development of ICSI-mediated gene transfer method in pigs (明治大学ハイテクリサーチセンター公開シンポジウ)
142.	2007/03	Production of live piglet from vitrified IVM/IVF embryos (明治大学ハイテクリサーチセンター公開シンポジウム)
143.	2007/03	Vitrification of porcine embryos derived from in vitro-matured oocytes:Development of a non-invasive method (明治大学ハイテクリサーチセンター公開シンポジウム)
144.	2007/01	Cryopreservation of porcine embryos derived from IVM oocytes ("33th Annual Meeting of International Embryo Transfer Society, Kyoto")
145.	2007/01	Foreign gene integration patterns in transgenic porcine fetuses produced by ICSI-mediated gene transfer (33th Annual Meeting of International Embryo Transfer Society)
146.	2007/01	Production of transgenic cloned pigs by means of somatic cell nuclear transfer using kusabira-orange gene transfected cells (33th Annual Meeting of International Embryo Transfer Society)
147.	2006/01	"Stage-specific of oxidative stress on developmental competence, ROS generation and DNA damage of porcine parthenogenetic embryos." (32nd Annual conference of international embryo transfer society)
148.	2006/01	Comparison of transgene expression by ICSI and pronuclear microinjection in murine and porcine embryos. (32nd Annual conference of international embryo transfer society)
149.	2006/01	Embryonic loss in pigs associated with oviduct transplantation of early-stage embryos with damages in the zona pellucida. (32nd Annual conference of international embryo transfer society)
150.	2006/01	Production of third-generation clones of a pig by somatic cell nuclear transfer. (32nd Annual conference of international embryo transfer society)
151.	2006/01	Successful pregnancies following transfer of virtified porcine embryos derived from in vitro-matured oocytes. (32nd Annual conference of international embryo transfer society)
152.	2005/01	Differential development of rabbit embryos following microinsemination using sperm and spermatids. (31th Annual conference of the international embryo transfer society)
153.	2005/01	Production of cloned pigs by nuclear transfer of preadipocytes. (31th Annual conference of the international embryo transfer society)
154.	2005/01	Production of cloned pigs from somatic stem cells derived from salivary grand. (31th Annual conference of the international embryo transfer society)
155.	2003	Comparison between electro-fusion and intracytoplasmic nuclear injection method in pig cloning. (29th Annual conference of the international embryo transfer society)
156.	2003	Effect of cytoplasmic replacement at MII stage on the development of mouse oocytes reconstructed by germinal vesicle transfer. (5th world conference of A-PART)
157.	2003	Improved survival of cryopreserved porcine morulae. (29th Annual conference of international embryos transfer society)
158.	2003	Production of normal offspring from mouse oocytes reconstructed by germinal vesicle replacement. (29th Annual conference of the international embryo transfer society)
159.	2003	Successful cryopreservation of porcine IVM-derived embryos. (29th Annual conference of the international embryo transfer society)
160.	2001/11	New strategies for efficient production of transgenic pigs. (The 18th Kumamoto medical bioscience symposium: Gene therapy and regenerative medicine)
161.	2001/10	Effect of oocyte activation timing on nuclear remodelling and development of porcine nuclear transfer embryos. (International workshop: Current status and perspectives in cloning and related studies)
162.	2001/10	New strategies for efficient production of transgenic pigs. (International workshop: Current status and perspectives in cloning and related studies)
163.	2001/09	Expression of GFP gene introduced into porcine in vitro matured oocytes by intracytoplasmic sperm injection. (Transgenic animal research conference III)
164.	2001/06	Tansgenic and modern reproductive technologies in the pig (Korean Society of Animal Science and Technology)
165.	2001/01	Cryopreservation of morula and early blastocyst stage swine embryos: birth of litters after embryo (27th Annual conference of the international embryo transfer society)
166.	2000/09	Non-invasive cryopreservation of zona pellucida intact morula stage pig embryos: Birth of multiple litters of piglets after embryo transfer
167.	2000/06	Nuclear remodeling and in vitro development of porcine muclear transfer embryos reconstructed with cumulus cell muclei.
168.	2000/03	Pig cloning by Honolulu method
169.	2000/02	Development of nuclear transfer in the pig
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■ Academic Qualifications

1.	1980/04～1984/03	Graduate School, Division of Agricultural Science, The University of Tokyo, Completed,
2.	1974/04～1978/03	Department of Agriculture, Faculty of Agriculture, Meiji University, Graduated,

■ Web Sites

http://www.isc.meiji.ac.jp/~nagaslab/index.html

■ Award History

2015/07

22nd International Meeting on Advanced Spine Techniques Whitecloud Award for Best Basic Science Paper (Generation of FBN1 gene knockout pig model for marfan syndrome)

■ Current Specialized Field

Animal production science

■ Patents

1.		BIOCOMPATIBLE CERAMIC-POLYMER HYBRIDS AND CALCIUM PHOSPHATE POROUS BODY
2.		Hollow fiber cryopreservation instrument and cell cryopreservation method