Faculty Database - Watanabe Hirohito

Books and Papers

Conference Presentations

Academic Qualifications

Research Topics, Consignment Studies & KAKENHI Researches

Current Specialized Field

KAKENHI Researcher Number

（Last updated : 2021-09-21 11:37:01）

Watanabe Hirohito
Department Undergraduate School , School of Agriculture

Position Professor

■ Books and Papers

1.	2019/06	Article	Identification of a novel advanced glycation end product derived from lactaldehyde. Biosci. Biotechnol. Biochem. 83(6),pp.1136-1145 (Collaboration)
2.	2018/09	Article	Identification of pyridinoline, a collagen crosslink, as a novel intrinsic ligand for the receptor for advanced glycation end-products (RAGE). Biosci. Biotechnol. Biochem. 82,pp.1508-1514 (Collaboration)
3.	2018/02	Article	Receptor for advanced glycation end products (RAGE)-mediated cytotoxicity of 3-hydroxypyridinium derivatives. Biosci. Biotechnol. Biochem. 82,pp.312-319 (Collaboration)
4.	2016/10	Article	Mechanisms of D-amino acid formation during maturation of sweet rice wine (mirin). Food Sci. Technol. Res. 22,pp.679-686 (Collaboration)
5.	2016/06	Article	Analysis of the cooked aroma and odorants that contribute to umami aftertaste of soy miso (Japanese soybean paste). Food Chem. 213,pp.521-528 (Collaboration)
6.	2015/04	Article	Inhibitory effect of oligomeric polyphenols from peanut-skin on sugar digestion enzymes and glucose transport. Food Sci. Technol. Res. 22,pp.679-686 (Collaboration)
7.	2010/12	Article	Identification of the blue pigment formed in a D-glucose-glycine reaction system Biosci. Biotechnol. Biochem. 74(12) (Collaboration)
8.	2010	Article	Chemistry of pigments as intermediate of melanoidins. The Maillard Reaction, Interface between Aging, Nutrition, and Metabolism pp.232-240 (Collaboration)
9.	2010	Article	Glyceraldehyde-derived advanced glycation end products decrease white adipose tissue weight and downregulate leptin, adiponectin, and macrophage marker. The Maillard Reaction, Interface between Aging, Nutrition, and Metabolism pp.51-57 (Collaboration)
10.	2009/10	Article	Identification of red pigments formed in a D-xylose-glycine reaction sysytem Biosci. Biotechnol. Biochem. 73(10),pp.2287-2292 (Collaboration)
11.	2008/04	Article	Formation mechanisms of melanoidins and fluorescent pyridinium compounds as advanced glycation end products Ann. NY Acad. Sci. 1126,pp.53-58 (Collaboration)
12.	2008/02	Article	The formation of argpyrimidine in glyceraldehyde-related glycation Biosci. Biotechnol. Biochem. 72(2),pp.568-571 (Collaboration)
13.	2008	Article	Biochemical and genomic analysis of neoculin compared to monocot mannose-binding lectins J. Agric. Food Chem. 56(3),pp.5338-5344 (Collaboration)
14.	2007/10	Article	Identification and determination of alpha-dicarbonyl compounds formed in the degradation of sugars Biosci. Biotechnol. Biochem. 71(10),pp.2465-2472 (Collaboration)
15.	2007/09	Article	Determination of glyceraldehyde formed in glucose degradation and glycation Biosci. Biotechnol. Biochem. 71(9),pp.2162-2168 (Collaboration)
16.	2007/02	Article	Detection and determination of glyceraldehyde-derived pyridinium-type advanved glycation end product in streptozotocin-induced diabetic rats Biosci. Biotechnol. Biochem. 71(2),pp.442-448 (Collaboration)
17.	2006/12	Article	Chemistry and some biological effects of model melanoidins and pigments as Maillard intermediates Mol. Nutr. Food Res. 50(12),pp.1171-1179 (Collaboration)
18.	2006/10	Article	Identification of a novel blue pigment as amelanoidin intermediate in the D-xylose-glycine reaction system Biosci. Biotechnol. Biochem. 70(10),pp.2529-2531 (Collaboration)
19.	2006/08	Article	Non-involvement of the human monocarboxylic acid transporter 1(MCT1) in the transport of phenolic acid Biosci. Biotechnol. Biochem. 70(8),pp.1928-1933 (Collaboration)
20.	2006/06	Article	Isolation and Identification of 5-methyl-imidazolin-4-one derivative as glyceraldehyde-derived advanced glycation end product Biosci. Biotechnol. Biochem. 70(6),pp.1496-1498 (Collaboration)
21.	2004/11	Article	Effect of a pore-forming protein derived from Flammulina velutipes on the Caco-2 intestinal epithelial cell monolayer Biosci. Biotechnol. Biochem. 68,pp.2230-2238 (Collaboration)
22.	2004/02	Article	Cytotoxicity and oxidative stress induced by the glyceraldehydes-related Maillard reaction products for HL-60 cells Biosci. Biotechnol. Biochem. 68,pp.333-340 (Collaboration)
23.	2004/01	Article	Protective effect of Blue-M1 against oxidative stress on COS-1 cells Biosci. Biotechnol. Biochem. 68,pp.247-249 (Collaboration)
24.	2004	Article	Detection and determination of glyceraldehydes- derived glycation end product BioFactors 21,pp.391-394 (Collaboration)
25.	2003/04	Article	Aquaporin-9 is expressed in a mucus-secreting goblet cell subset in the small intestine FEBS Lett. 540,pp.157-162 (Collaboration)
26.	2003/04	Article	Evaluation of intestinal dioxin permeability using human Caco-2 cell monolayers Food Sci. Technol. Res. 9,pp.364-366 (Collaboration)
27.	2001/02	Article	Induction of Nitric Oxide Synthase and Subsequent Production of Nitric Oxide Not Involved in Interferon-r-induced Hyperpermeability of Caco-2 Intestinal Epithelial Monolayers Biosci. Biotechnol. Biochem. 65巻・2号,pp.428-430 (Collaboration)
28.	2000	Article	Acetic acid suppresses the increase in disaccharidase activity that occurs during culture of Caco-2 cells. Journal of Nutrition 130,pp.507-513
29.	1999	Article	Purification and cDNA cloning of a protein derived from Flammulina velutipes that increases the permeability of the intestinal Caco-2 cell monolayer. European Journal of Biochemistry 262,pp.850-857
30.	1998	Article	System b┣D10,+┫D1-mediated regulation of lysine transport in Caco-2 human intestinal cells(共著) Amino Acids 14,pp.379-384
31.	1997	Article	Characterization and regulation of taurine transport in Caco-2, human intestinal cells (共著) Journal of Biochemistry 121,pp.1082-1087
32.	1997	Article	Oryzasin as an aspartic proteinase occurring in rice seeds : purification, characterization, and application to milk clotting (共著) Journal of Agricultural and Food Chemistry 45,pp.1070-1075
33.	1996	Article	Structural organization of the gene encoding corn cystatin (共著) Biosciene, Biotechnology, and Biochemistry 60,pp.1173-1175
34.	1996	Article	Transgenic rice established to express corn cystatin exhibits strong inhibitory activity against insect gut proteinases (共著) Plant Molecular Biology 30,pp.149-157
35.	1995	Article	A Putative Digestive Cysteine Proteinase from Droesophila melanogaster is Predominantly Expressed in the Embryonic and Larval Midgut (共著) European Journal of Biochemistry 227,pp.582-587
36.	1995	Article	Isolation and characterization of two distinct cDNA clones encoding corn seed cysteine proteinases (共著) Biochimica et Biophysica Acta 1263,pp.241-244
37.	1995	Article	Rice aspartic proteinase, oryzasin, expressed during seed ripening and germination, has a gene organization distinct from those of animal and microbial aspartic proteinases (共著) European Journal of Biochemistry 232,pp.77-83
38.	1994	Article	Gibberellin-inducible Cysteine Proteinase pp.1-8
39.	1992	Article	Gibberellin-responsive Gene Expression Taking Place with Oryzains α and γ as Cysteine Proteinases of Rice Seeds (共著) Bioscience, Biotechnology, and Biochemistry 56,pp.1154-1155
40.	1991	Article	Molecular Cloning and Gibberellin-induced Expression of Multiple Cysteine Proteinases of Rice Seeds (共著) Journal of Biological Chemistry 266,pp.16897-16902
41.	1991	Article	Orzacystatins as the First Well-defined Cystatins of Plant Origin and Their Target Proteinases in Rice Seeds (共著) Biomedica et Biochimica Acta 50,pp.637-641
42.	1991	Article	Papain-inhibitory Activity of Oryzacystatin, a Rice Seed Cysteine Proteinase Inhibitor, Depends on the Central Gln-Val-Val-Ala-Gly Region Conserved among Cystatin Superfamily (共著) Journal of Biochemistry 109,pp.294-298
43.	1990	Article	Two Distinct Cystatin Species in Rice Seeds with Deferent Specificities against Cysteine Proteinases : Molecular Cloning, Expression, and Biochemical Studies on Oryzacystatin II (共著) Journal of Biological Chemistry 265,pp.15832-15837
44.	2005/06	Book	Chemistry and biological effects of melanoidins and glyceraldehydes-derived pyridinium as advanced glycation end products v.1043 no. pp.104-110 (Collaboration)
45.	2005/06	Book	Degradation of amadori compounds by flavin adenine dinucleotide v.1043 no. pp.897 (Collaboration)
46.	2005/06	Book	Isolation and identification of glyceraldehydes-　derived advanced glycation end products v.1043 no. pp.899 (Collaboration)
47.	2002	Book	"Formation and determination of α-dicarbonyls and a AGE cross-link, pyrropyridine in glycated proteins and in vivo v.1245 no." pp.153-156 (Collaboration)
48.	2002	Book	3-deoxy- glucosone-related advanced glycation end products in foods and biological systems v.1245 no. pp.217-221 (Collaboration)
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■ Conference Presentations

1.	2001/10	3-deoxyosone related advanced glycation endproducts in foods and biological systems
2.	2001/10	Formation and determination of α-dicarbonyls and an AGE crosslink, pyrropyridine, in glycated proteins and in vivo
3.	2000/11	A protein derived from Flammulina velutipes that enhances paracellular permeability of Caco-2 intestinal epithelial cells

■ Academic Qualifications

1.	1990/04～1993/03	〔Doctorial Course〕, Graduate School, Division of Agricultural Science, The University of Tokyo,
2.	1988/04～1990/03	Faculty of Agriculture, The University of Tokyo,

■ Research Topics, Consignment Studies & KAKENHI Researches

1.	2000～	Studies on physiological effects of the Maillard reaction products (Key Word : Maillard reaction,diabetic complications,)
2.	1995～	Studies on function of intestinal epithelial cells (Key Word : intestinal epithelial cells,,)
3.		Molecular Biological Study on Plant Protein (Key Word : Rice,Molecular Cloning,Protease)

■ Current Specialized Field

Applied biochemistry , Food sciences

■ KAKENHI Researcher Number

20270895