Faculty Database - NAGATAKE TAKAHIRO

Books and Papers

Conference Presentations

Academic Qualifications

Career History

Major Subjects

Web Sites

Email Addresses

Award History

Current Specialized Field

（Last updated : 2024-04-20 00:06:42）

NAGATAKE TAKAHIRO
Department Undergraduate School , School of Agriculture

Position Associate Professor

■ Books and Papers

1.	2024/01	Article	Alcaligenes lipid A functions as a superior mucosal adjuvant to monophosphoryl lipid A via the recruitment and activation of CD11b+ dendritic cells in nasal tissue International Immunology 36(1),pp.33-43 (Collaboration)
2.	2024/01	Article	Linkage-Editing Pseudo-Glycans: A Reductive α-Fluorovinyl-C-Glycosylation Strategy to Create Glycan Analogs with Altered Biological Activities. J Am Chem Soc 146(3),pp.2237-2247 (Collaboration)
3.	2023/08	Article	Lentinula Edodes Mycelia extract regulates the function of antigen-presenting cells to activate immune cells and prevent tumor-induced deterioration of immune function BMC Complement Med Ther 23(1),pp.281 (Collaboration)
4.	2023/04	Article	Dietary iodine attenuates allergic rhinitis by inducing ferroptosis in activated B cells Scientific Reports 13(1),pp.5398 (Collaboration)
5.	2023/04	Article	Induction of unique macrophage subset by simultaneous stimulation with LPS and IL-4 Frontiers in Immunology 14,pp.1111729 (Collaboration)
6.	2023/02	Article	Anti-allergic property of dietary phytoestrogen secoisolariciresinol diglucoside through microbial and β-glucuronidase-mediated metabolism The Journal of Nutritional Biochemistry 112,pp.109219 (Collaboration)
7.	2023/02	Article	Mead acid inhibits retinol-induced irritant contact dermatitis via peroxisome proliferator-activated receptor alpha. Frontiers in Molecular Biosciences 10,pp.1097955 (Collaboration)
8.	2023/02	Article	TLR4 agonist activity of Alcaligenes lipid A utilizes MyD88 and TRIF signaling pathways for efficient antigen presentation and T cell differentiation by dendritic cells. International Immunopharmacology 117,pp.109852 (Collaboration)
9.	2022/08	Article	Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota. Nature Communications 13(1) (Collaboration)
10.	2022/02	Article	Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques. Mucosal Immunology 15(2),pp.289-300 (Collaboration)
11.	2021/10	Article	Chemically Synthesized Alcaligenes Lipid A as an Adjuvant to Augment Immune Responses to Haemophilus Influenzae Type B Conjugate Vaccine. Frontiers in Pharmacology (Collaboration)
12.	2021/07	Article	Lipopolysaccharide derived from the lymphoid-resident commensal bacteria Alcaligenes faecalis functions as an effective nasal adjuvant to augment IgA antibody and Th17 cell responses. Frontiers in Pharmacology (Collaboration)
13.	2021/05	Article	12-Hydroxyeicosapentaenoic acid inhibits foam cell formation and ameliorates high-fat diet-induced pathology of atherosclerosis in mice. Scientific Reports 11(1) (Collaboration)
14.	2021/05	Article	Mechanisms underlying enhanced IgA production in Peyer’s patch cells by membrane vesicles derived from Lactobacillus sakei. Bioscience, Biotechnology, and Biochemistry 85(6),pp.1536-1545 (Collaboration)
15.	2021/05	Article	Selective expression of claudin-5 in thymic endothelial cells regulates the blood-thymus barrier and T-cell export. International Immunology 33(3),pp.171-182 (Collaboration)
16.	2021/04	Article	ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α. The FASEB Journal 35(4) (Collaboration)
17.	2020/10	Article	Emerging Roles of ω3 Fatty Acid Metabolites in the Regulation of Allergic and Inflammatory Diseases pp.53-62 (Collaboration)
18.	2020/09	Article	Lymphoid tissue-resident Alcaligenes establish an intracellular symbiotic environment by creating a unique energy shift in dendritic cells. (Collaboration)
19.	2020/08	Article	Maternal ω3 docosapentaenoic acid inhibits infant allergic dermatitis through TRAIL-expressing plasmacytoid dendritic cells in mice. Allergy 75(8),pp.1939-1955 (Collaboration)
20.	2020/07	Article	Adjuvant activity of synthetic lipid A of Alcaligenes, a gut-associated lymphoid tissue-resident commensal bacterium, to augment antigen-specific IgG and Th17 responses in systemic vaccine. Vaccines 8(3) (Collaboration)
21.	2020/07	Article	Chemically synthesized Alcaligenes lipid A shows a potent and safe nasal vaccine adjuvant activity for the induction of Streptococcus pneumoniae-specific IgA and Th17 mediated protective immunity. Microorganisms 8(8) (Collaboration)
22.	2020/07	Article	Impaired mucociliary motility enhances antigen-specific nasal IgA immune responses to cholera toxin-based nasal vaccine. International Immunology 32(8),pp.559-568 (Collaboration)
23.	2020/07	Article	Vitamin B1 supports the differentiation of T cells through TGF-β superfamily production in thymic epithelial cells. iScience (Collaboration)
24.	2020/02	Article	Persistent colonization of non-lymphoid tissue-resident macrophages by Stenotrophomonas maltophilia. International Immunology 32(2),pp.133-141 (Collaboration)
25.	2020/01	Article	Claudin 4 in pancreatic βcells is involved in regulating the functional state of adult islets. FEBS Open Bio 10(1),pp.28-40 (Collaboration)
26.	2019/12	Article	17(S),18(R)-epoxyeicosatetraenoic acid generated by cytochrome P450 BM-3 from Bachillus megaterium inhibits the development of contact hypersensitivity via G-protein-coupled receptor 40-mediated neutrophil suppression. FASEB Bioadvances 2(1),pp.59-71 (Collaboration)
27.	2019/11	Article	Dietary omega-3 fatty acid dampens allergic rhinitis via eosinophilic production of the anti-allergic lipid mediator 15-hydroxyeicosapentaenoic acid in mice. Nutrients 11(12) (Collaboration)
28.	2019/09	Article	BLT1 mediates commensal bacteria-dependent innate immune signals to enhance antigen-specific intestinal IgA responses. Mucosal Immunology 12(5),pp.1082-1091 (Collaboration)
29.	2019/08	Article	Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice. Allergy 74(8),pp.1522-1532 (Collaboration)
30.	2019/08	Article	Emerging roles of metabolites of　ω3 and ω6 essential fatty acids in the control of intestinal inflammation. International Immunology 31(9),pp.569-577 (Collaboration)
31.	2019/04	Article	Host- and microbe-dependent dietary lipid metabolism in the control of allergy, inflammation and immunity. Frontiers in Nutrition 6(36) (Collaboration)
32.	2019/02	Book	Lymphoid Tissues Associated with Gastrointestinal (GI) Mucosa. Lymph Node Metastasis in Gastrointestinal Cancer pp.111-126 (Collaboration)
33.	2019/02	Article	Development of a bivalent food poisoning vaccine: augmented antigenicity of the C-terminus of Clostridium perfringens enterotoxin by fusion with the B subunit of Escherichia coli Shiga toxin 2. International Immunology 31(2),pp.91-100 (Collaboration)
34.	2018/09	Article	Immunological association of inducible bronchus-associated lymphoid tissue organogenesis in Ag85B-rHPIV2 vaccine-induced anti-tuberculosis mucosal immune responses in mice. International Immunology 30(10),pp.471-481 (Collaboration)
35.	2018/08	Article	The 17,18-epoxyeicosatetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques. The Journal of Allergy and Clinical Immunology 142(2),pp.470-484 (Collaboration)
36.	2018/04	Article	Obesity suppresses cell-competition-mediated apical elimination of RasV12-transformed cells from epithelial tissues. Cell Reports 23(4),pp.974-982 (Collaboration)
37.	2018/02	Article	Impaired airway mucociliary function reduces antigen-specific IgA response to immunization with a claudin-4-targeting nasal vaccine in mice. Scientific Reports 8(1) (Collaboration)
38.	2017/10	Article	High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδT cells. Scientific Reports 7(1) (Collaboration)
39.	2017/01	Article	Method for preparing DNA from feces in guanidine thiocyanate solution affects 16S rRNA-based profiling of human microbiota diversity. Scientific Reports 7(1),pp.4339 (Collaboration)
40.	2016/12	Article	Inhaled fine particles induce alveolar macrophage death and interleukin-1α release to promote inducible bronchus-associated lymphoid tissue formation. Immunity 45(6),pp.1299-1310 (Collaboration)
41.	2016/12	Article	粘膜関連リンパ組織のユニーク性と臨床応用リンパ学 39(2),pp.80-87 (Collaboration)
42.	2015/10	Article	Mode of bioenergetic metabolism during B cell differentiation in the intestine determines the distinct requirement for vitamin B1. Cell Reports 13(1),pp.122-131 (Collaboration)
43.	2015/06	Article	Salt-inducible kinase 3 deficiency exacerbates lipopolysaccharide-induced endotoxin shock accompanied by increased levels of pro-inflammatory molecules in mice. Immunology 145(2),pp.268-278 (Collaboration)
44.	2015/05	Article	Central role of core binding factor β2 in mucosa-associated lymphoid tissue organogenesis in mouse. PLoS One 10(5),pp.e0127460 (Collaboration)
45.	2015/05	Article	腸管組織における多元的免疫制御システムと食物アレルギー医学のあゆみ: 粘膜免疫Update 253(5),pp.451-456 (Collaboration)
46.	2015/01	Article	Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut. Scientific Reports 11(5),pp.9750 (Collaboration)
47.	2014/03	Article	Enteroendocrine cells are specifically marked by cell surface expression of claudin-4 in mouse small intestine. PLoS One 9(6),pp.e90638 (Collaboration)
48.	2013/12	Article	Unique function of mucosa-associated lymphoid tissues as targets of mucosal vaccines. Current Topics in Pharmacology 17(1),pp.13-23 (Collaboration)
49.	2012/04	Article	Implications of nasopharynx-associated lymphoid tissue (NALT) in the development of allergic responses in an allergic rhinitis mouse model. Allergy 67(4),pp.502-509 (Collaboration)
50.	2011/05	Article	A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. Cell Host and Microbe 9(5),pp.376-389 (Collaboration)
51.	2011/04	Article	The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigens. The Journal of Immunology 186(7),pp.4253-4262 (Collaboration)
52.	2009/10	Article	Id2-, RORγt-, and LTβR-independent initiation of lymphoid organogenesis in ocular immunity. The Journal of Experimental Medicine 206(11),pp.2351-2364 (Collaboration)
53.	2009/04	Book	Mucosa-associated lymphoid tissue and dynamics of lymphoid cells in the five different compartments in allergic diseases. Allergy Frontiers: Classification and Pathomechanisms pp.563-601 (Collaboration)
54.	2007/11	Article	Regulatory role of lymphoid chemokine CCL19 and CCL21 in the control of allergic rhinitis. The Journal of Immunology 179(9),pp.5897-5906 (Collaboration)
55.	2007/03	Article	Intranasal immunization with phosphorylcholine induces antigen specific mucosal and systemic immune responses in mice. Vaccine 25(14),pp.2680-2687 (Collaboration)
56.	2006/10	Article	Uniqueness of lymphoid chemokine requirement for the initiation and maturation of nasopharynx-associated lymphoid tissue organogenesis. The Journal of Immunology 177(7),pp.4276-4280 (Collaboration)
57.	2006/01	Article	粘膜免疫機構とケモカインアレルギー・免疫: ケモカインとアレルギー 13(1),pp.38-44 (Collaboration)
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■ Conference Presentations

1.	2022/12/09	Activation of MyD88- and TRIF-mediated Signaling Pathways by Alcaligenes Lipid A for Efficient Antigen Presentation and T Cell Differentiation by Dendritic Cells. (第51回日本免疫学会学術集会)
2.	2022/12/08	Adjuvant activity of chemically synthesized Alcaligenes Lipid A to augment immune responses against Haemophilus Influenzae type B conjugate vaccine. (第51回日本免疫学会学術集会)
3.	2022/12/07	Mead acid (5,8,11-eicosatrienoic acid) inhibits retino-l-induced irritant contact dermatitis through PPARα-mediated pathway. (第51回日本免疫学会学術集会)
4.	2022/11	Unique carbohydrate and amino acid metabolisms of Blautia wexlerae ameliorate obesity and type 2 diabetes. (The 9th International Human Microbiome Consortium)
5.	2022/10	Unique metabolism of Blautia wexlerae has beneficial effects on the control of obesity and type 2 diabetes. (The 9th World Congress on Targeting Microbiota)
6.	2022/09	Activation of MyD88- and TRIF-mediated Signaling Pathways by Alcaligenes Lipid A for Efficient Antigen Presentation and T Cell Differentiation by Dendritic Cells. (2022 International Society for Vaccines Annual Congress)
7.	2022/09	Chemically Synthesized Alcaligenes Lipid A as an Adjuvant to Augment Immune Responses to Haemophilus Influenzae Type B Conjugate Vaccine. (2022 International Society for Vaccines Annual Congress)
8.	2021/12/09	A symbiotic mechanism of intestinal lymphoid tissue resident Alcaligenes by controlling metabolic modification in dendritic cells. (第50回日本免疫学会学術集会)
9.	2021/12/09	Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases. (第50回日本免疫学会学術集会)
10.	2021/12/09	Omega-3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, inhibits allergic contact dermatitis through retinoid X receptor α in keratinocytes. (第50回日本免疫学会学術集会)
11.	2021/10/13	Effective and safe adjuvant activity of Alcaligenes LPS and its synthetic lipid A for nasal vaccine. (16th Meeting of the International Endotoxin and Innate Immune Society)
12.	2021/03/23	A symbiotic relationship between intestinal lymphoid tissue resident Alcaligenes and dendritic cells. (第94回日本細菌学会総会)
13.	2021/03/23	Synthetic lipid A of Alcaligenes augments nasal vaccine efficacy to prevent pneumococcal infection. (第94回日本細菌学会総会)
14.	2021/01/14	Emerging roles of ω3 and ω6 essential fatty acid metabolites in the control of immunity, allergic and inflammatory diseases. (Chiba University-IMSUT Joint Seminar)
15.	2020/07	Enhancement of intestinal IgA production via Peyer’s patch dendritic cells by membrane vesicles derived from lactic acid bacteria (Lactobacillus sakei). (International Society for Extracellular Vesicles 2020 Virtual Annual Meeting)
16.	2020/05/10	Airway mucociliary dysfunction enhances antigen-specific nasal IgA immune responses to cholera toxin-based nasal vaccine. (The 104th Annual Meeting of The American Association of Immunologists (Immunology2020))
17.	2020/05/09	Microbial enzyme stereoselectively converts EPA into 17(S),18(R)-epoxyeicosatetraenoic acid useful for the amelioration of contact hypersensitivity. Evaluation of anti-inflammatory activity of enantiometric 17,18-epoxyeicosatetraenoic acid in contact hypersensitivity. (The 104th Annual Meeting of The American Association of Immunologists (Immunology2020))
18.	2020/01/21	Chemically synthesized Alcaligenes lipid A augments nasal vaccine effect to prevent pneumococcal infection through Th17 response. (第13回次世代アジュバント研究会)
19.	2020/01/21	Lymphoid-resident commensal bacteria Alcaligenes-derived lipid A as an effective vaccine adjuvant to augument Th17 responses. (第13回次世代アジュバント研究会)
20.	2019/12/13	Defects in asymmetrical beating of airway epithelial cell cilia enhances antigen-specific nasal IgA immune responses to cholera toxin-based nasal vaccine. (第48回日本免疫学会学術集会)
21.	2019/12/13	Evaluation of anti-inflammatory activity of enantiometric 17,18-epoxyeicosatetraenoic acid in contact hypersensitivity. (第48回日本免疫学会学術集会)
22.	2019/12/12	Microbe-dependent metabolite of α-linolenic acid alleviates contact hypersensitivity by inhibiting the development of inducible skin-associated lymphoid tissue. (第48回日本免疫学会学術集会)
23.	2019/07/18	BLT1 enhances gut IgA production against oral vaccine by inducing commensal bacteria-dependent proliferation of plasma cells. (The 19th International Congress of Mucosal Immunology (ICMI))
24.	2019/06/19	BLT1 promotes intestinal IgA production against oral vaccine by mediating commensal bacteria-dependent innate immune signals for plasma cell proliferation. (The 60th International Conference on the Bioscience of Lipids)
25.	2018/12/11	Immunological association of inducible bronchus-associated lymphoid tissue organogenesis in Ag85B-rHPIV2 vaccine-induced anti-tuberculosis mucosal immune responses in mice. (第47回日本免疫学会学術集会)
26.	2018/10/30	Augmentation of antigenicity of the C-terminal region of Clostridium perfringens enterotoxin by fusion with the B subunit of Escherichia coli Shiga toxin 2 for the development of bivalent food poisoning vaccine. (2018 Annual Congress International Society for Vaccines)
27.	2018/09/12	Development of a bivalent food poisoning vaccine: augmented antigenicity of C-terminal region of Clostridium perfringens enterotoxin by fusion with Escherichia coli Shiga toxin 2 B subunit. (第16回松山国際学術シンポジウム&若手の会)
28.	2017/12/14	Metabolic demand of colonic macrophages for symbiotic and cytosolic colonization by non-lymphoid tissue resident commensal bacteria. (第46回日本免疫学会学術集会)
29.	2017/12/13	17,18-EpETE, a metabolite of omega-3 essential fatty acids, inhibited neutron mobility and ameliorated skin inflammation in DNFB-induced contact hypersensitivity model. (第46回日本免疫学会学術集会)
30.	2017/10/11	Development of a bivalent vaccine against Clostridium perfringens enterotoxin and enterohemorrhagic Escherichia coli Vero toxin 2. (The 9th Conference of Vaccines for Enteric Diseases)
31.	2017/05/16	17,18-epoxyeicosatetoraenoic acid impairs neutron mobility and ameliorates contact hypersensitivity. (The 1st Japan-Korea Joint Meeting on Mucosal Immunology)
32.	2016/12/05	17,18-epoxy-eicosatetraenoic acid ameliorated contact hypersensitivity by inhibiting neutrophil infiltration into the skin. (第45回日本免疫学会学術集会)
33.	2016/08/26	Immunological involvement of airway mucociliary function in the claudin-4-targeting pneumococcal nasal vaccine. (The 16th International Congress of Immunology)
34.	2016/08/25	Contact hypersensitivity is ameliorated by 17,18-epoxy-eicosatetraenoic acid, a metabolite from eicosapentaenoic acid, in the skin. (The 16th International Congress of Immunology)
35.	2016/05/14	Inducible bronchus-associated lymphoid tissue plays an important role in the induction of antigen-specific immune response by Ag85B-hPIV2-based anti-tuberculosis vaccine in mice. (The 100th Annual Meeting of The American Association of Immunologists (Immunology2016))
36.	2015/11/20	Prevention of gut and skin allergic inflammation by 17,18-epoxy-eicosatetraenoic acid, an endogenously generated lipid metabolite from linseed oil. (第44回日本免疫学会学術集会)
37.	2015/11/19	Immunological involvement of airway cilium in the induction of antigen-specific immune responses against nasally immunized pneumococcal vaccine using claudin binder. (第44回日本免疫学会学術集会)
38.	2015/02/10	Dietary ω3 fatty acid-originated 17,18-epoxyeicostetraenoic acid prevents the development of allergic inflammation in the gut and skin. (The 6th International Conference on Phospholipase A2 and Lipid Mediators)
39.	2013/12/11	Eye immune responses initiated by uniquely developing tear duct-associated lymphoid tissue. (第42回日本免疫学会学術集会)
40.	2012/12/05	Claudin-5 is a crucial component of blood-thymus barrier by regulating vascular permeability. (第41回日本免疫学会学術集会)
41.	2012/11/05	Claudin-5 plays a role in establishing specific thymic microenvironment by regulating vascular permeability. (ThymUS 2012 International Conference)
42.	2008/12/02	Role of Id2, RORγt and Cbfβ2 for Differentiation of Mucosa-associated CD3^-CD4⁺CD45⁺ Lymphoid Tissue Inducer Cells. (第38回日本免疫学会総会・学術集会)
43.	2008/04	Genesis of tear duct-associated lymphoid tissue is independent of Id2, RORγt but requires Cbfβ2 transcriptional regulator. (The 95th Annual Meeting of The American Association of Immunologists)
44.	2007/11	Degradation of Amadori compound by flavin adenine dinucleotide. (International Conference on Food Factors for Health Promotion 2007)
45.	2006/09/05	Distinct subsets of lymphoid tissue inducer cells: RORγt independent CD3^-CD4^lowCD45⁺ cells are responsible for the NALT-genesis. (The 6th Awaji International Forum on Infection and Immunity)
46.	2005/12	Unique Chemokine Receptors Expression between NALT and Peyer’s Patch Inducer Cells. (第35回日本免疫学会総会・学術集会)
47.	2005/06	Different Organogenesis Associated Gene Expression between NALT and Peyer’s Patch CD3^-CD4⁺CD45⁺ Inducer Cells. (The 12th International Congress of Mucosal Immunology)
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■ Academic Qualifications

1.	2000/04～2004/03	Department of Life Sciences, School of Agriculture, Meiji University, Graduated,
2.	2004/04～2006/03	〔Master Course〕, The University of Tokyo, Completed,
3.	2006/04～2010/03	〔Doctorial Course〕, The University of Tokyo, Completed,

■ Career History

1.	2010/12～2012/12	Kyoto University Laboratory of Immunology and Cell Biology Researher Postdoc
2.	2013/01～2022/03	National Institutes of Biomedical Innovation, Health and Nutrition Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental Systems Chief Researcher
3.	2022/04～	Meiji University Laboratory of Functional Anatomy, Department of Life Sciences, School of Agriculture Associate Professor

■ Web Sites

https://meiji-lifesci.jp/master/長竹%E3%80%80貴広/

■ Email Addresses

■ Award History

2022/12

Japanese Society for Immunology International Immunology Outstanding Merit Award 2021 (Selective expression of claudin-5 in thymic endothelial cells regulates the blood-thymus barrier and T-cell export)

■ Current Specialized Field

Immunology